评估儿童饮食相关神经认知缺陷的生物标志物--系统综述

Dietetics Pub Date : 2024-07-26 DOI:10.3390/dietetics3030021
Fiifi Amoako Atta Panyin Essiam, Mary Amoako, R. Khanna
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引用次数: 0

摘要

儿童的神经认知缺陷可能是不可逆的,对儿童的整体健康不利。通常情况下,患有这种疾病的儿童无法发挥其精神和智力潜能。本文旨在回顾炎症生物标志物与儿童神经认知之间关系的主要证据。本文系统地检索了 Scopus、Cochrane Library 和 PubMed 等电子数据库,以收录 2000 年至 2023 年 10 月间所有已发表的数据。关键词包括血清生物标志物、认知、执行功能、智力、脑源性神经营养因子、神经认知缺陷、tau 蛋白和儿童。共获得 8512 篇期刊论文,但在去除重复、评论和综述性论文后,有 9 篇论文被接受审阅。C反应蛋白、脑源性神经营养因子(BDNF)、肿瘤坏死因子α(TNF-α)、纤维蛋白原、血浆瘦素、可溶性肿瘤坏死因子受体1(sTNFR1)和铜与受试者的神经认知相关。综述显示,目前还没有关于撒哈拉以南非洲地区的研究发表,而且大多数研究的样本量都很小。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomarkers for Assessing Diet-Related Neurocognitive Deficits in Children—A Systematic Review
Neurocognitive deficits in children could be irreversible and detrimental to the overall wellbeing of children. Typically, children with this illness live lives below their mental and intellectual potential. The aim of this paper was to review primary evidence on the association between inflammatory biomarkers on neurocognition in children. Electronic databases such as Scopus, Cochrane Library, and PubMed were systematically searched to include all published data from 2000 to October 2023. The keywords included serum biomarker, cognition, executive function, intellectual ability, brain-derived neurotrophic factor, neurocognitive deficits, tau proteins, and children. A total of 8512 journal publications were obtained, but after the removal of duplicates, commentaries, and review papers, 9 papers were accepted for review. C-reactive protein, brain-derived neurotrophic factor (BDNF) tumor necrosis factor alpha (TNF-α), fibrinogen, plasma leptin, soluble tumor necrosis factor receptor 1 (sTNFR1), and copper were associated with neurocognition in the subjects. This review revealed that there is no research published in sub-Saharan Africa and most of the sample sizes in the studies were small.
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