银屑病患者的牙周炎:流行病学见解和可能的致病联系

F. Di Spirito, Maria Pia Di Palo, Antonio Rupe, Federica Piedepalumbo, Alessandra Sessa, Giuseppina De Benedetto, Serena Russo Barone, M. Contaldo
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引用次数: 0

摘要

牛皮癣是一种主要影响皮肤的全身性自身免疫性疾病,表现为红斑和鳞屑,影响着全球约 2-3% 的人口。慢性牙周炎是一种常见的口腔疾病,其特征是牙齿支撑组织遭到破坏,影响着全球约 10-15% 的成年人。流行病学研究表明,银屑病患者中牙周炎的发病率较高,反之亦然,新的证据表明银屑病和慢性牙周炎之间存在双向关系。这两种疾病都是慢性炎症性疾病,其特点是免疫反应失调和细胞因子谱改变,特别是涉及 TNF-α 和 IL-17 等促炎细胞因子。临床研究强调了治疗一种疾病对另一种疾病的相互影响,突出了皮肤科医生和牙周病医生在管理两种疾病患者时进行跨学科合作的必要性。这篇叙述性综述全面概述了银屑病和慢性牙周炎之间的关系,研究了流行病学关联、共同的炎症途径、遗传学见解、微生物菌群失调、环境因素和临床影响。该综述强调了综合护理方法的重要性,以及有针对性的治疗干预对改善银屑病和牙周病患者预后的潜力,并倡导进一步研究这些疾病的分子和细胞机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Periodontitis in Psoriatic Patients: Epidemiological Insights and Putative Etiopathogenic Links
Psoriasis, a systemic autoimmune disorder primarily affecting the skin, manifests through erythematous plaques and scales, impacting approximately 2–3% of the global population. Chronic periodontitis, a prevalent oral disease characterized by the destruction of tooth-supporting tissues, affects roughly 10–15% of adults worldwide. Emerging evidence suggests a bidirectional relationship between psoriasis and chronic periodontitis, supported by epidemiological studies indicating a higher prevalence of periodontitis among individuals with psoriasis and vice versa. Both conditions are chronic inflammatory diseases marked by dysregulated immune responses and altered cytokine profiles, notably involving proinflammatory cytokines such as TNF-α and IL-17. Clinical studies highlight a reciprocal impact of treating one condition on the other, underscoring the necessity of interdisciplinary collaboration between dermatologists and periodontists in managing patients with both conditions. This narrative review provides a comprehensive overview of the relationship between psoriasis and chronic periodontitis, examining epidemiological associations, shared inflammatory pathways, genetic insights, microbial dysbiosis, environmental factors, and clinical implications. The review emphasizes the importance of integrated care approaches and the potential for targeted therapeutic interventions to improve both psoriatic and periodontal patient outcomes, advocating for further research into the molecular and cellular mechanisms underpinning the comorbidity of these diseases.
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