探索抗抑郁药物对重度抑郁症患者的治疗潜力的电复律法:文献综述

IF 7.5 1区 医学 Q1 BEHAVIORAL SCIENCES
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引用次数: 0

摘要

重度抑郁障碍(MDD)的特征是至少有一次重度抑郁发作。患者需要接受治疗,通常需要服用抗抑郁药物。由于抗抑郁药物的疗效有限,MDD 患者的病情往往难以得到缓解。如今,许多患者都在接受各种抗抑郁治疗,并定期监测其个人经历的主观变化。因此,必须找到临床客观工具,为选择抗抑郁药物提供更有针对性的方法。视网膜的神经化学成分与大脑相似,对需要抗抑郁治疗的 MDD 患者进行视网膜电图(ERG)测量是一种很有前景的方法。因此,本综述旨在强调不同类别的抗抑郁药对 MDD 患者视网膜功能的影响,评估方法包括全场 ERG(ffERG)、模式 ERG(PERG)和多焦点 ERG(mfERG)波形。这些ERG测量结果可作为确定患者特征的关键指标,有助于采用更客观、更个性化的方法进行治疗干预,从而推动精准精神病学的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ElectroRetinoGraphy toward an exploration of the therapeutic potential of antidepressants in patients with major depressive disorder: A scoping review of the literature

Major Depressive Disorder (MDD) is characterized by at least one major depressive episode. It requires medical attention typically involving the prescription of antidepressants. Remission in MDD patients is often difficult to achieve because of the limited effectiveness of these drugs. Nowadays, numerous patients undergo various antidepressant treatments, with subjective changes in their personal experiences being regularly monitored. Therefore, it is essential to find clinical and objective tools that offer a more tailored approach to antidepressant selection. The neurochemistry of the retina being similar to the brain, one promising approach would be to use ElectroRetinoGraphy (ERG) measurements on MDD patients requiring antidepressant treatment. Thus, the aim of this scoping review is to highlight effects of different classes of antidepressants on retinal function evaluated by full-field ERG (ffERG), Pattern ERG (PERG) and multifocal ERG (mfERG) waveforms in MDD patients. These ERG measurements could serve as pivotal indicators in defining patient profiles, facilitating a more objective and personalized approach to therapeutic interventions, thereby advancing precision psychiatry.

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来源期刊
CiteScore
14.20
自引率
3.70%
发文量
466
审稿时长
6 months
期刊介绍: The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.
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