全面回顾量子点在癌症治疗方面的经验教训。

Javad Mohammadi, Ali Hheidari, Sohrab Sardari, Moein Nouri, Sina Ebrahimi, Abbas Rahdar, Esmail Pishbin
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引用次数: 0

摘要

量子点(QDs)具有优异的物理化学和生物特性,因此在癌症治疗领域具有广泛的应用前景。量子点的主要特征之一是其独特的电子结构,这赋予了它们功能属性。值得注意的是,它们的光致发光既强又可调,因此可有效地用于基于荧光的识别,如生物传感和生物成像。此外,QDs 还具有令人印象深刻的载货能力,使其成为药物输送应用的理想选择。此外,吸收入射辐射的能力使 QDs 成为光动力疗法等杀癌技术的理想候选材料。本综述旨在全面介绍将 QDs 用作多功能创新生物材料的最新进展。本综述重点阐明了 QDs 的生物、电子和物理化学特性,并讨论了 QD 合成技术的进步。此外,它还深入探讨了基于生物传感、生物成像和治疗应用(包括药物输送和坏死)的 QDs 诊断应用所取得的进展,强调了它们在癌症治疗领域的巨大潜力。此外,该综述还探讨了目前 QDs 在癌症治疗中的局限性,并对未来的发展方向提出了宝贵的见解,从而促进了该领域的进一步发展。这篇综述综述全面、结构合理,是一份权威的信息资源,可以指导未来的研究工作,促进 QDs 在癌症治疗领域的不断进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A comprehensive review of lessons learned from quantum dots in cancer therapy.

Quantum dots (QDs) are with exceptional physicochemical and biological properties, making them highly versatile for a wide range of applications in cancer therapy. One of the key features of QDs is their unique electronic structure, which gives them functional attributes. Notably, their photoluminescence can be strong and adjustable, allowing them to be effectively used in fluorescence based diagnosis such as biosensing and bioimaging. In addition, QDs demonstrate an impressive capacity for loading cargo, making them ideal for drug delivery applications. Moreover, their ability to absorb incident radiation positions QDs as promising candidates for cancer-killing techniques like photodynamic therapy. The objective of this comprehensive review is to present a current and comprehensive overview of the recent advancements in utilizing QDs as multifunctional and innovative biomaterials. This review focuses on elucidating the biological, electronic, and physicochemical properties of QDs, along with discussing the technical advancements in QD synthesis. Furthermore, it thoroughly explores the progress made in utilizing QDs for diagnosis based on biosensing, bioimaging, and therapy applications including drug delivery and necrosis, highlighting their significant potential in the field of cancer treatment. Furthermore, the review addresses the current limitations associated with QDs in cancer therapy and provides valuable insights into future directions, thereby facilitating further advancements in this field. By presenting a comprehensive and well-structured overview, this review serves as an authoritative and informative resource that can guide future research endeavors and foster continued progress in the field of QDs for cancer therapy.

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