β-羟丁酸与缺血性中风:作用与机制。

IF 3.3 3区 医学 Q2 NEUROSCIENCES
Ge Feng, Zongkai Wu, Leyi Yang, Kaimeng Wang, Hebo Wang
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引用次数: 0

摘要

中风是全球的一个重大负担,会导致广泛的发病率和死亡率。在葡萄糖受限的代谢状态下,酮体(主要是 β-羟基丁酸(BHB))可作为替代燃料来源。在中风动物模型的缺血半球中已发现 BHB 水平升高,支持其在脑缺血病理生理学中的作用。在临床上,血清和尿液中较高的 BHB 浓度与缺血性中风的不良预后有关,突显了其作为预后生物标志物的潜在作用。在动物模型和细胞模型中,外源性 BHB 给药具有神经保护作用,可缩小梗死面积,改善神经功能预后。在本综述中,我们将重点讨论 BHB 在缺血性脑卒中前后的作用,并着重探讨缺血性脑卒中后酮类给药的治疗潜力和机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
β-hydroxybutyrate and ischemic stroke: roles and mechanisms.

Stroke is a significant global burden, causing extensive morbidity and mortality. In metabolic states where glucose is limited, ketone bodies, predominantly β-hydroxybutyrate (BHB), act as alternative fuel sources. Elevated levels of BHB have been found in the ischemic hemispheres of animal models of stroke, supporting its role in the pathophysiology of cerebral ischemia. Clinically, higher serum and urinary BHB concentrations have been associated with adverse outcomes in ischemic stroke, highlighting its potential utility as a prognostic biomarker. In both animal and cellular models, exogenous BHB administration has exhibited neuroprotective effects, reduction of infarct size, and improvement of neurological outcomes. In this review, we focus on the role of BHB before and after ischemic stroke, with an emphasis on the therapeutic potential and mechanisms of ketone administration after ischemic stroke.

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来源期刊
Molecular Brain
Molecular Brain NEUROSCIENCES-
CiteScore
7.30
自引率
0.00%
发文量
97
审稿时长
>12 weeks
期刊介绍: Molecular Brain is an open access, peer-reviewed journal that considers manuscripts on all aspects of studies on the nervous system at the molecular, cellular, and systems level providing a forum for scientists to communicate their findings. Molecular brain research is a rapidly expanding research field in which integrative approaches at the genetic, molecular, cellular and synaptic levels yield key information about the physiological and pathological brain. These studies involve the use of a wide range of modern techniques in molecular biology, genomics, proteomics, imaging and electrophysiology.
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