挖掘寄生虫作为新型癌症治疗药物的潜力。

IF 2.8 4区 医学 Q2 ONCOLOGY
Neha Sylvia Walter, Shalmoli Bhattacharyya
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引用次数: 0

摘要

尽管最近在癌症的管理和治疗方面取得了进展,但癌症的治疗因其高昂的费用和严重的副作用而受到限制。在这种情况下,为这种可怕的疾病寻找新型替代治疗方法的需求尚未得到满足。最近,越来越多的证据表明,寄生虫可能具有抗癌作用,因为寄生虫感染与肿瘤生长之间存在负相关关系,尽管有些寄生虫具有促癌作用。据观察,寄生虫通过激活宿主的免疫反应或分泌某些具有抗癌潜力的分子来发挥抗癌作用。这些寄生生物激活的免疫反应可抑制肿瘤增殖、血管生成和转移等一些癌症特征。这篇综述总结了目前的研究进展以及这组不同生物作为抗癌剂可能产生影响的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mining parasites for their potential as novel therapeutic agents against cancer.

Mining parasites for their potential as novel therapeutic agents against cancer.

Despite recent advances in the management and therapeutic of cancer, the treatment of the disease is limited by its high cost and severe side effects. In this scenario, there is an unmet need to identify novel treatment alternatives for this dreaded disease. Recently there is growing evidence that parasites may cause anticancer effects because of a negative correlation between parasitic infections and tumour growth despite some parasites that are known to exhibit pro-carcinogenic effects. It has been observed that parasites exert an anticancer effect either by activating the host's immune response or by secreting certain molecules that exhibit anticancer potential. The activation of the immune response by these parasitic organisms results in the inhibition of some of the hallmarks of cancer such as tumour proliferation, angiogenesis, and metastasis. This review summarizes the current advances as well as the mechanisms underlying the possible implications of this diverse group of organisms as anticancer agents.

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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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