日本多发性硬化症患者病情进展与复发活动无关的特征：一项为期两年的多中心队列研究。

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2024-07-24 DOI:10.1016/j.jneuroim.2024.578407

Hiroaki Yokote , Yusei Miyazaki , Juichi Fujimori , Yoichiro Nishida , Shuta Toru , Masaaki Niino , Ichiro Nakashima , Yoshiharu Miura , Takanori Yokota

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引用次数: 0

摘要

独立于复发活动的进展（PIRA）在白种复发性和缓解性多发性硬化症（RRMS）患者中非常普遍。然而，人们对亚洲 RRMS 患者的 PIRA 特征了解有限。因此，我们回顾性分析了95名日本RRMS患者在2年观察期内的临床和放射学进展。结果发现，3 名患者出现了 PIRA，他们的特点是年龄小、T2 病灶体积大、脑容量减少。尽管疾病高度活跃，但与无疾病活动的患者（60.7%）相比，PIRA 患者接受高效药物治疗的比例较低（33.3%）。

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Characterization of Japanese multiple sclerosis patients with progression independent of relapse activity: A 2-year multicenter cohort study

Progression independent of relapse activity (PIRA) is prevalent among Caucasian patients with relapsing and remitting multiple sclerosis (RRMS). However, there is limited knowledge regarding the characteristics of PIRA in Asian patients with RRMS. Therefore, we retrospectively analyzed the clinical and radiological progression of 95 Japanese patients with RRMS during a 2-year observation period. PIRA was observed in three patients who were characterized by young age, large T2 lesion volume, and great reduction in brain volume. Despite having highly active disease, fewer patients with PIRA (33.3%) were treated with high-efficacy drugs compared with those without disease activity (60.7%).

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.