探索作为帕金森病生物标志物的环状 RNA 及其在有氧运动康复后的表达变化。

IF 3.9 4区 生物学 Q1 GENETICS & HEREDITY
Flávia Maria Campos de Abreu, Deborah Almeida de Oliveira, Sabrina Simplício de Araujo Romero Ferrari, Karla Helena Coelho Vilaça e Silva, Ricardo Titze-de-Almeida, Simoneide Souza Titze-de-Almeida
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引用次数: 0

摘要

环状核糖核酸(circRNA)是环化的单链核糖核酸,可与 DNA、RNA 和蛋白质相互作用,在细胞生物学中发挥关键作用。环状核糖核酸可调节微核糖核酸的含量和基因表达,并可编码特定的肽。事实上,circRNA 在帕金森病(PD)等神经退行性疾病中的表达存在差异,在大脑病理机制中发挥着潜在的作用。在大脑中异常表达的 RNA 分子可穿过血脑屏障进入血液,因此可用作帕金森病的非侵入性生物标志物。在联合 circRNA 标志中,具有重要鉴别能力的有望靶点包括 MAPK9_circ_0001566、SLAIN1_circ_0000497、SLAIN2_circ_0126525、PSEN1_circ_0003848、circ_0004381 和 circ_0017204。另一方面,定期锻炼是减轻帕金森病症状的有效疗法,通过表观遗传调节促进神经保护作用。有氧运动可改善运动控制、改善高级功能、增强大脑活动和神经病理学,从而减缓帕金森病的症状进展。这些改善伴随着循环RNA表达的变化,包括hsa_circ_0001535(circFAM13B)和hsa_circ_0000437(circCORO1C)。目前检测循环 circRNA 方法的灵敏度被认为是一个局限。虽然已有用于低丰度 microRNA 的扩增试剂盒,但 circRNA 还需要类似的试剂盒。另外,使用数字 PCR 也有助于克服这一限制。本综述探讨了将 circRNAs 用作帕金森病非侵入性生物标志物和评估康复效果的可能性。尽管circRNAs有望成为帕金森病诊断和治疗的靶标,但在临床应用前仍需进一步验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exploring circular RNAs as biomarkers for Parkinson’s disease and their expression changes after aerobic exercise rehabilitation

Exploring circular RNAs as biomarkers for Parkinson’s disease and their expression changes after aerobic exercise rehabilitation

Circular RNAs (circRNAs) are circularized single-stranded ribonucleic acids that interacts with DNA, RNA, and proteins to play critical roles in cell biology. CircRNAs regulate microRNA content, gene expression, and may code for specific peptides. Indeed, circRNAs are differentially expressed in neurodegenerative disorders like Parkinson’s disease (PD), playing a potential role in the mechanisms of brain pathology. The RNA molecules with aberrant expression in the brain can cross the blood–brain barrier and reach the bloodstream, which enable their use as non-invasive PD disease biomarker. Promising targets with valuable discriminatory ability in combined circRNA signatures include MAPK9_circ_0001566, SLAIN1_circ_0000497, SLAIN2_circ_0126525, PSEN1_circ_0003848, circ_0004381, and circ_0017204. On the other hand, regular exercises are effective therapy for mitigating PD symptoms, promoting neuroprotective effects with epigenetic modulation. Aerobic exercises slow symptom progression in PD by improving motor control, ameliorating higher functions, and enhancing brain activity and neuropathology. These improvements are accompanied by changes circRNA expression, including hsa_circ_0001535 (circFAM13B) and hsa_circ_0000437 (circCORO1C). The sensitivity of current methods for detecting circulating circRNAs is considered a limitation. While amplification kits already exist for low-abundant microRNAs, similar kits are needed for circRNAs. Alternatively, the use of digital PCR can help overcome this constraint. The current review examines the potential use of circRNAs as non-invasive biomarkers of PD and to assess the effects of rehabilitation. Although circRNAs hold promise as targets for PD diagnosis and therapeutics, further validation is needed before their clinical implementation.

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来源期刊
CiteScore
3.50
自引率
3.40%
发文量
92
审稿时长
2 months
期刊介绍: Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?
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