含有 PCH2N 单元的甘氨酸官能化有机磷类似物的合成

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-07-26 DOI:10.1007/s11172-024-4290-y

Yu. N. Bubnov, A. A. Prishchenko, M. V. Livantsov, O. P. Novikova, L. I. Livantsova, S. V. Baranin

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引用次数: 0

摘要

我们已经开发出了合成一系列含有氨甲基以及杂杂环和氨基酸分子的甘氨酸有机磷类似物的简便方法。用氯、烷氧基和氨基取代的甲基（二烷基）胺对膦酸酯进行氨甲基化，可得到各种新的功能化氨甲基膦酸盐和双（氨甲基）膦酸盐。由此产生的化合物有望成为生物活性物质、萃取剂和水溶性配体。

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Synthesis of functionalized organophosphorus analogs of glycine containing PCH2N units

Convenient methods for the synthesis of a series of organophosphorus analogs of glycine containing aminomethyl groups as well as azaheterocyclic and amino acid moieties have been developed. Aminomethylation of phosphinic acid esters with chloro-, alkoxy- and amino-substituted methyl(dialkyl)amines affords various new functionalized aminomethylphosphonites and bis(aminomethyl)phosphinates. The resulting compounds are of interest as promising biologically active substances, extractants, and water-soluble ligands.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.