M. S. Fedorova, A. E. Gatina, V. N. Ilyina, L. L. Yadykova, V. V. Drukker, A. S. Gorshkova, A. R. Kayumov, E. Y. Trizna
{"title":"来自贝加尔湖支流的一种新的噬菌假单胞菌噬菌体 Ka1","authors":"M. S. Fedorova, A. E. Gatina, V. N. Ilyina, L. L. Yadykova, V. V. Drukker, A. S. Gorshkova, A. R. Kayumov, E. Y. Trizna","doi":"10.1134/s0026261723604906","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The bacteriophage <i>Pseudomonas</i> phage Ka1 was isolated from the water of a tributary stream of Lake Baikal, in the area of discharge of treated wastewater of the city of Slyudyanka. The bacteriophage genome contains 46 092 bp and has a 50% G+C pairs (AN OP455935.1). It exhibits 91% identity with the <i>Pseudomonas</i> phage PSA37 genome, belonging to <i>Bruynoghevirus</i> from the class <i>Caudoviricetes</i> suggesting that Ka1 is a new representative of Luz24-like phages (<i>Bruynoghevirus</i>). The bacteriophage lyzes 62% of <i>P. aeruginosa</i> clinical isolates and increases the efficiency of gentamicin, ciprofloxacin, imipenem and meropenem by 4–8-fold against these bacteria. Integrases, transposases and recombinases have not been identified in the genome of the bacteriophage <i>Pseudomonas</i> phage Ka1; which allows using it in the complex therapy of infections caused by <i>P. aeruginosa.</i></p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A New Bacteriophage Pseudomonas Phage Ka1 from a Tributary Stream of Lake Baikal\",\"authors\":\"M. S. Fedorova, A. E. Gatina, V. N. Ilyina, L. L. Yadykova, V. V. Drukker, A. S. Gorshkova, A. R. Kayumov, E. Y. Trizna\",\"doi\":\"10.1134/s0026261723604906\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3 data-test=\\\"abstract-sub-heading\\\">Abstract</h3><p>The bacteriophage <i>Pseudomonas</i> phage Ka1 was isolated from the water of a tributary stream of Lake Baikal, in the area of discharge of treated wastewater of the city of Slyudyanka. The bacteriophage genome contains 46 092 bp and has a 50% G+C pairs (AN OP455935.1). It exhibits 91% identity with the <i>Pseudomonas</i> phage PSA37 genome, belonging to <i>Bruynoghevirus</i> from the class <i>Caudoviricetes</i> suggesting that Ka1 is a new representative of Luz24-like phages (<i>Bruynoghevirus</i>). The bacteriophage lyzes 62% of <i>P. aeruginosa</i> clinical isolates and increases the efficiency of gentamicin, ciprofloxacin, imipenem and meropenem by 4–8-fold against these bacteria. Integrases, transposases and recombinases have not been identified in the genome of the bacteriophage <i>Pseudomonas</i> phage Ka1; which allows using it in the complex therapy of infections caused by <i>P. aeruginosa.</i></p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1134/s0026261723604906\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s0026261723604906","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
A New Bacteriophage Pseudomonas Phage Ka1 from a Tributary Stream of Lake Baikal
Abstract
The bacteriophage Pseudomonas phage Ka1 was isolated from the water of a tributary stream of Lake Baikal, in the area of discharge of treated wastewater of the city of Slyudyanka. The bacteriophage genome contains 46 092 bp and has a 50% G+C pairs (AN OP455935.1). It exhibits 91% identity with the Pseudomonas phage PSA37 genome, belonging to Bruynoghevirus from the class Caudoviricetes suggesting that Ka1 is a new representative of Luz24-like phages (Bruynoghevirus). The bacteriophage lyzes 62% of P. aeruginosa clinical isolates and increases the efficiency of gentamicin, ciprofloxacin, imipenem and meropenem by 4–8-fold against these bacteria. Integrases, transposases and recombinases have not been identified in the genome of the bacteriophage Pseudomonas phage Ka1; which allows using it in the complex therapy of infections caused by P. aeruginosa.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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