甲状腺激素的生物合成及其在大脑发育和维护中的作用。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Janaina Sena de Souza
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引用次数: 0

摘要

甲状腺激素是几乎所有组织所必需的生理过程中的关键调节剂,在大脑发育和维护中发挥着特别重要的作用。这些激素调节神经元迁移、突触生成和髓鞘化等重要的神经发育过程。此外,甲状腺激素对于维持成年期的大脑稳态和认知功能也至关重要。本章旨在全面介绍甲状腺激素的生物合成及其在大脑生理学中的复杂作用。在这里,我们描述了甲状腺激素生物合成的基本机制、它们对大脑发育和持续维持的各个方面的影响,以及大脑中对这些激素有反应的蛋白质。本章旨在拓宽我们对甲状腺激素在大脑中作用的认识,为神经发育和神经退行性疾病的潜在治疗靶点提供启示。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Thyroid hormone biosynthesis and its role in brain development and maintenance.

Thyroid hormones are critical modulators in the physiological processes necessary to virtually all tissues, with exceptionally fundamental roles in brain development and maintenance. These hormones regulate essential neurodevelopment events, including neuronal migration, synaptogenesis, and myelination. Additionally, thyroid hormones are crucial for maintaining brain homeostasis and cognitive function in adulthood. This chapter aims to offer a comprehensive understanding of thyroid hormone biosynthesis and its intricate role in brain physiology. Here, we described the mechanisms underlying the biosynthesis of thyroid hormones, their influence on various aspects of brain development and ongoing maintenance, and the proteins in the brain that are responsive to these hormones. This chapter was geared towards broadening our understanding of thyroid hormone action in the brain, shedding light on potential therapeutic targets for neurodevelopmental and neurodegenerative disorders.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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