靶向脂肪因子:治疗癫痫病的前景广阔的策略

IF 3.7 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Iqraa Shaikh, Lokesh Kumar Bhatt
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引用次数: 0

摘要

癫痫影响着全球 6500 万人,并导致神经行为、认知和心理缺陷。尽管对这种疾病的研究正在取得进展,并有多种治疗方法可供选择,但仍有约 30% 的人患有难治性癫痫,无法用常规药物治疗。这凸显了进一步了解这种疾病并探索前沿治疗目标的重要性。脂肪因子是脂肪细胞白色脂肪组织分泌的多肽,参与控制食物摄入和新陈代谢。它们在中枢神经系统(CNS)中的调控功能是多方面的,并在多种生理和病理现象中被发现。脂肪因子在氧化应激和神经炎症中发挥作用,而氧化应激和神经炎症与大脑退化和相关神经疾病有关。本综述旨在强调瘦素、脂肪连素、apelin、vaspin、visfatin 和 chimerin 在癫痫发病机制中的潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Targeting Adipokines: A Promising Therapeutic Strategy for Epilepsy

Targeting Adipokines: A Promising Therapeutic Strategy for Epilepsy

Epilepsy affects 65 million people globally and causes neurobehavioral, cognitive, and psychological defects. Although research on the disease is progressing and a wide range of treatments are available, approximately 30% of people have refractory epilepsy that cannot be managed with conventional medications. This underlines the importance of further understanding the condition and exploring cutting-edge targets for treatment. Adipokines are peptides secreted by adipocyte’s white adipose tissue, involved in controlling food intake and metabolism. Their regulatory functions in the central nervous system (CNS) are multifaceted and identified in several physiology and pathologies. Adipokines play a role in oxidative stress and neuroinflammation which are associated with brain degeneration and connected neurological diseases. This review aims to highlight the potential impacts of leptin, adiponectin, apelin, vaspin, visfatin, and chimerin in the pathogenesis of epilepsy.

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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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