头颈部软组织肉瘤:39 例患者的临床和组织病理学研究。

IF 1 Q3 OTORHINOLARYNGOLOGY
Polish Journal of Otolaryngology Pub Date : 2024-07-25
Jarosław Markowski, Anna Długosz-Karbowska, Monika Ciupińska, Wojciech Smółka, Zuzanna Dobrosz, Aleksandra Ślaska-Kaspera, Olga Lesniewska-Skowerska, Wirginia Likus, Klaudia Mazurek
{"title":"头颈部软组织肉瘤:39 例患者的临床和组织病理学研究。","authors":"Jarosław Markowski, Anna Długosz-Karbowska, Monika Ciupińska, Wojciech Smółka, Zuzanna Dobrosz, Aleksandra Ślaska-Kaspera, Olga Lesniewska-Skowerska, Wirginia Likus, Klaudia Mazurek","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Soft tissue sarcomas (STS) constitute about 1-2% of all malignant tumors, with approximately 10% of them located in the head and neck region.&lt;b&gt;Aim:&lt;/b&gt; The aim of this study was the assessment of treatment efficiency in head and neck STS of adult patients of the ENT Department of Medical University of Silesia, treated surgically in the period 1980-2023.&lt;b&gt;Materials and methods:&lt;/b&gt; Retrospective analysis of 39 patients with the diagnosis of head and neck STS.&lt;b&gt;Results:&lt;/b&gt; Histopathological examination showed 21 different types of STS located most commonly in: paranasal sinuses (13 cases), orbital cavity (6 cases), nasal cavity (3 cases), and larynx (3 cases). Other locations: parapharyngeal space, parotid gland, nasal septum, bridge of the nose, soft and hard palate, mandibular mucosa, tongue, auricle, palatine tonsil, and cheek. All those patients underwent chemoradiation as postoperative treatment. Radical surgical procedure was achieved in 32 patients (82%). However, in 11 patients (28%), microscopic examination did not confirm radical resection (R1 - PSM - positive surgical margin). In 7 patients (18%), the surgical procedure turned out to be not radical on macroscopic examination (R2). Dissemination of neoplasms (distant metastases) was found in 7 patients (18%). Five-year survival time without local recurrence was achieved in 25 patients (64%). The most frequent reason for unsuccessful interventions was local recurrence noted in 18 patients (46%), while distant metastases occurred in 9 patients (23%).&lt;b&gt;Conclusions:&lt;/b&gt; The basic procedure in the treatment of STS is radical surgery combined with preoperative or postoperative radiotherapy and/or chemotherapy and, in case of a metastasis, surgical removal thereof. Despite the fact that sarcomas are rare tumors, they remain a challenge for head and neck surgery. Recurrence rates and mortality remain high due to the high degree of malignancy.</p>","PeriodicalId":42608,"journal":{"name":"Polish Journal of Otolaryngology","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Soft tissue sarcomas of the head and neck region: clinical and histopathological study of 39 patients.\",\"authors\":\"Jarosław Markowski, Anna Długosz-Karbowska, Monika Ciupińska, Wojciech Smółka, Zuzanna Dobrosz, Aleksandra Ślaska-Kaspera, Olga Lesniewska-Skowerska, Wirginia Likus, Klaudia Mazurek\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>&lt;b&gt;Introduction:&lt;/b&gt; Soft tissue sarcomas (STS) constitute about 1-2% of all malignant tumors, with approximately 10% of them located in the head and neck region.&lt;b&gt;Aim:&lt;/b&gt; The aim of this study was the assessment of treatment efficiency in head and neck STS of adult patients of the ENT Department of Medical University of Silesia, treated surgically in the period 1980-2023.&lt;b&gt;Materials and methods:&lt;/b&gt; Retrospective analysis of 39 patients with the diagnosis of head and neck STS.&lt;b&gt;Results:&lt;/b&gt; Histopathological examination showed 21 different types of STS located most commonly in: paranasal sinuses (13 cases), orbital cavity (6 cases), nasal cavity (3 cases), and larynx (3 cases). Other locations: parapharyngeal space, parotid gland, nasal septum, bridge of the nose, soft and hard palate, mandibular mucosa, tongue, auricle, palatine tonsil, and cheek. All those patients underwent chemoradiation as postoperative treatment. Radical surgical procedure was achieved in 32 patients (82%). However, in 11 patients (28%), microscopic examination did not confirm radical resection (R1 - PSM - positive surgical margin). In 7 patients (18%), the surgical procedure turned out to be not radical on macroscopic examination (R2). Dissemination of neoplasms (distant metastases) was found in 7 patients (18%). Five-year survival time without local recurrence was achieved in 25 patients (64%). The most frequent reason for unsuccessful interventions was local recurrence noted in 18 patients (46%), while distant metastases occurred in 9 patients (23%).&lt;b&gt;Conclusions:&lt;/b&gt; The basic procedure in the treatment of STS is radical surgery combined with preoperative or postoperative radiotherapy and/or chemotherapy and, in case of a metastasis, surgical removal thereof. Despite the fact that sarcomas are rare tumors, they remain a challenge for head and neck surgery. Recurrence rates and mortality remain high due to the high degree of malignancy.</p>\",\"PeriodicalId\":42608,\"journal\":{\"name\":\"Polish Journal of Otolaryngology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polish Journal of Otolaryngology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polish Journal of Otolaryngology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

<b>引言:</b>软组织肉瘤(STS)约占所有恶性肿瘤的1-2%,其中约10%位于头颈部。<b>目的:</b>本研究旨在评估1980-2023年期间接受手术治疗的西里西亚医科大学耳鼻喉科成年患者头颈部STS的治疗效果。<b>材料与方法:</b>回顾性分析了 39 名确诊为头颈部 STS 的患者。<b>结果:</b>组织病理学检查显示,21 种不同类型的 STS 最常见于以下部位:副鼻窦(13 例)、眼眶(6 例)、鼻腔(3 例)和喉部(3 例)。其他位置:咽旁间隙、腮腺、鼻中隔、鼻梁、软腭和硬腭、下颌粘膜、舌、耳廓、腭扁桃体和颊。所有这些患者都在术后接受了化疗。32名患者(82%)接受了根治性手术治疗。然而,有 11 名患者(28%)的显微镜检查未确认根治性切除(R1 - PSM - 手术切缘阳性)。7名患者(占18%)的宏观检查结果显示手术并非根治性切除(R2)。7名患者(18%)发现肿瘤扩散(远处转移)。25名患者(64%)的五年存活期内未出现局部复发。最常见的治疗失败原因是局部复发,有 18 例患者(46%),而远处转移有 9 例患者(23%)。尽管肉瘤是罕见肿瘤,但仍是头颈部外科手术的难题。由于恶性程度高,复发率和死亡率居高不下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Soft tissue sarcomas of the head and neck region: clinical and histopathological study of 39 patients.

<b>Introduction:</b> Soft tissue sarcomas (STS) constitute about 1-2% of all malignant tumors, with approximately 10% of them located in the head and neck region.<b>Aim:</b> The aim of this study was the assessment of treatment efficiency in head and neck STS of adult patients of the ENT Department of Medical University of Silesia, treated surgically in the period 1980-2023.<b>Materials and methods:</b> Retrospective analysis of 39 patients with the diagnosis of head and neck STS.<b>Results:</b> Histopathological examination showed 21 different types of STS located most commonly in: paranasal sinuses (13 cases), orbital cavity (6 cases), nasal cavity (3 cases), and larynx (3 cases). Other locations: parapharyngeal space, parotid gland, nasal septum, bridge of the nose, soft and hard palate, mandibular mucosa, tongue, auricle, palatine tonsil, and cheek. All those patients underwent chemoradiation as postoperative treatment. Radical surgical procedure was achieved in 32 patients (82%). However, in 11 patients (28%), microscopic examination did not confirm radical resection (R1 - PSM - positive surgical margin). In 7 patients (18%), the surgical procedure turned out to be not radical on macroscopic examination (R2). Dissemination of neoplasms (distant metastases) was found in 7 patients (18%). Five-year survival time without local recurrence was achieved in 25 patients (64%). The most frequent reason for unsuccessful interventions was local recurrence noted in 18 patients (46%), while distant metastases occurred in 9 patients (23%).<b>Conclusions:</b> The basic procedure in the treatment of STS is radical surgery combined with preoperative or postoperative radiotherapy and/or chemotherapy and, in case of a metastasis, surgical removal thereof. Despite the fact that sarcomas are rare tumors, they remain a challenge for head and neck surgery. Recurrence rates and mortality remain high due to the high degree of malignancy.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Polish Journal of Otolaryngology
Polish Journal of Otolaryngology OTORHINOLARYNGOLOGY-
CiteScore
1.30
自引率
16.70%
发文量
15
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信