阿尔茨海默病：细胞和药理学方面。

IF 2.1 Q3 GERIATRICS & GERONTOLOGY

Geriatrics Pub Date : 2024-06-22 DOI:10.3390/geriatrics9040086

Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, María Elena Hernández-Aguilar, Deissy Herrera-Covarrubias, Lizbeth Donají Chí-Castañeda, María Rebeca Toledo-Cárdenas, Jorge Manuel Suárez-Medellín

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引用次数: 0

摘要

阿尔茨海默氏症早在 100 多年前就被描述出来，尽管有几种分子正在接受治疗试验，并已进入第三阶段试验，但该疾病仍在继续发展。主要问题在于，这些分子在健康的神经元中能正常发挥作用，而神经元病理学包括质膜破坏、各种细胞器功能失常、Tau 和淀粉样蛋白斑块过度磷酸化。本文的主要目的是讨论一种神经元修复疗法，在这种疗法中，为治疗阿尔茨海默病而设计的分子可能会更有效，人们的生活质量也会更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Alzheimer's Disease: Cellular and Pharmacological Aspects.

Alzheimer's disease was described more than 100 years ago and despite the fact that several molecules are being tested for its treatment, which are in phase III trials, the disease continues to progress. The main problem is that these molecules function properly in healthy neurons, while neuronal pathology includes plasma membrane disruption, malfunction of various organelles, and hyperphosphorylation of Tau and amyloid plaques. The main objective of this article is the discussion of a neuronal restoration therapy, where molecules designed for the treatment of Alzheimer's disease would probably be more effective, and the quality of life of people would be better.

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来源期刊

Geriatrics 医学-老年医学

CiteScore

3.30

自引率

0.00%

发文量

115

审稿时长

20.03 days

期刊介绍： • Geriatric biology • Geriatric health services research • Geriatric medicine research • Geriatric neurology, stroke, cognition and oncology • Geriatric surgery • Geriatric physical functioning, physical health and activity • Geriatric psychiatry and psychology • Geriatric nutrition • Geriatric epidemiology • Geriatric rehabilitation