单细胞染色质可及性和转座元件景观揭示了组织驻留免疫细胞的共同特征

IF 25.5 1区 医学 Q1 IMMUNOLOGY
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引用次数: 0

摘要

器官内的调节性 T(Treg)细胞功能需要组织适应。这一程序是否与其他组织定位的免疫群体有相同之处尚不清楚。在这里,我们分析了单细胞染色质可及性数据,包括来自结肠、皮肤、脂肪组织和脾脏的 CD45+ 免疫细胞的转座元件(TE)图谱。我们发现了不同免疫细胞的器官特异性组织适应特征。以组织Treg细胞为重点,我们发现Treg组织适应程序在其他组织定位的免疫细胞中也有保留,如产生两性胰岛素的T辅助细胞(Th)17。可获取的TE可作为调控元件,但它们对组织适应的贡献尚不清楚。TE景观分析表明,在可访问染色质峰内的TE区域富集了特定的转录因子结合基序。TE,特别是LTR家族的TE,位于增强子区域,与组织适应有关。这些发现拓宽了我们对免疫组织驻留的理解,为实现器官特异性免疫干预迈出了重要一步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells

Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells

Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations is unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45+ immune cells from colon, skin, adipose tissue, and spleen. We identified features of organ-specific tissue adaptation across different immune cells. Focusing on tissue Treg cells, we found conservation of the Treg tissue adaptation program in other tissue-localized immune cells, such as amphiregulin-producing T helper (Th)17 cells. Accessible TEs can act as regulatory elements, but their contribution to tissue adaptation is not understood. TE landscape analysis revealed an enrichment of specific transcription factor binding motifs in TE regions within accessible chromatin peaks. TEs, specifically from the LTR family, were located in enhancer regions and associated with tissue adaptation. These findings broaden our understanding of immune tissue residency and provide an important step toward organ-specific immune interventions.

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来源期刊
Immunity
Immunity 医学-免疫学
CiteScore
49.40
自引率
2.20%
发文量
205
审稿时长
6 months
期刊介绍: Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.
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