先天性梅毒--新生儿使用替代抗生素治疗的综合叙述性评论。

IF 2.4 4区医学 Q3 INFECTIOUS DISEASES

Sexually transmitted diseases Pub Date : 2024-12-01 Epub Date: 2024-07-24 DOI:10.1097/OLQ.0000000000002057

Diana D Villarreal, Jennifer Le, Jeffrey D Klausner

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引用次数: 0

摘要

摘要：从2012年到2022年，美国先天性梅毒发病率增长了10倍。目前，治疗标准是静脉注射（IV）结晶青霉素 G 水剂 10 天，但替代品的证据非常有限。静脉注射抗生素的疗程较长，需要住院治疗，这对儿童和家庭来说既昂贵又是负担。幸运的是，根据最低抑菌浓度（MIC），苍白螺旋体对其他抗生素仍有敏感性。根据不同抗生素在新生儿中使用的安全性和有效性证据，头孢曲松成为治疗先天性梅毒的潜在肠外用药候选药物，阿莫西林成为治疗先天性梅毒的潜在口服候选药物。其他替代治疗药物包括头孢他啶（如有）、氨苄西林、强力霉素、头孢克肟和利奈唑胺。

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Congenital Syphilis-Comprehensive Narrative Review of Alternative Antibiotic Treatment for Use in Neonates.

Abstract: Congenital syphilis rates increased 10-fold from 2012 to 2022 in the United States. Currently, the therapeutic standard of care is 10 days of intravenous aqueous crystalline penicillin G, with very limited evidence for alternatives. A long course of intravenous antibiotic requires hospitalization that is both costly and burdensome for the child and the family. Fortunately, Treponema pallidum retains susceptibility to other antibiotics based on minimum inhibitory concentrations. Based on the evidence of safety and efficacy of different antibiotics for use in neonates, ceftriaxone emerges as a potential parenteral candidate, and amoxicillin emerges as a potential oral candidate for the treatment of congenital syphilis. Other therapeutic alternatives include cefotaxime (where available), ampicillin, doxycycline, cefixime, and linezolid.

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来源期刊

Sexually transmitted diseases 医学-传染病学

CiteScore

4.00

自引率

16.10%

发文量

289

审稿时长

3-8 weeks

期刊介绍： Sexually Transmitted Diseases, the official journal of the American Sexually Transmitted Diseases Association, publishes peer-reviewed, original articles on clinical, laboratory, immunologic, epidemiologic, behavioral, public health, and historical topics pertaining to sexually transmitted diseases and related fields. Reports from the CDC and NIH provide up-to-the-minute information. A highly respected editorial board is composed of prominent scientists who are leaders in this rapidly changing field. Included in each issue are studies and developments from around the world.