Zhi-Yuan Chen, Rong-Shuang Cheng, Wubulikasimu Ayixia, Yu-Shuang Liu, Kai-Bo Wang
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引用次数: 0
摘要
DNA G-四叠体(G4)是一种富含鸟嘌呤的单链 DNA 序列,可在癌基因启动子序列和端粒中自发折叠成球形的四链 DNA 二级结构。G4 与癌症的发生和发展高度相关,已成为有前景的抗癌靶点。长期以来,天然产物一直是抗癌药物开发的重要来源。近年来,以DNA G4为靶点的天然药物的发现取得了重大进展,许多DNA G4已被证实为天然产物的有望靶点,包括MYC-G4、KRAS-G4、PDGFR-β-G4、BCL-2-G4、VEGF-G4和端粒G4。本综述总结了发现靶向 DNA G4 的天然小分子及其结合机制的研究进展。它还讨论了开发 DNA G4 靶向药物的机遇和挑战。这篇综述将为天然产物研究,尤其是新型抗肿瘤药物的开发提供有价值的参考。
[Research progress in targeting DNA G-quadruplexes using natural products].
DNA G-quadruplex(G4) is a guanine-rich single-stranded DNA sequence that spontaneously folds into a spherical four-stranded DNA secondary structure in oncogene promoter sequences and telomeres. G4s are highly associated with the occurrence and development of cancer and have emerged as promising anticancer targets. Natural products have long been important sources of anticancer drug development. In recent years, significant progress has been made in the discovery of natural drugs targeting DNA G4s, with many DNA G4s have been confirmed as promising targets of natural products, including MYC-G4, KRAS-G4, PDGFR-β-G4, BCL-2-G4, VEGF-G4, and telomeric G4. This review summarizes the research progress in discovering natural small molecules that target DNA G4s and their binding mechanisms. It also discusses the opportunities of and challenges in developing drugs targeting DNA G4s. This review will serve as a valuable reference for the research on natural products, particularly in the development of novel antitumor medications.