用刮除术和光动力疗法联合成功治疗一名青少年的泛发性面部疣：病例报告

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-22 DOI:10.2147/ccid.s470435

Na Zhang, Xinru Chen, Tianhui Ye, Hongping Ge, Xiaoli Zhai, Jun Wu, Min Zhang, Meiyan Wang

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引用次数: 0

摘要

摘要：寻常疣是由人类乳头瘤病毒引起的皮肤角化性病变，具有高度传染性。一般来说，寻常疣对人体无害，但如果发生在脸部或脚底等特定部位，就会严重影响个人的生活质量，必须进行治疗干预。虽然目前有多种药物和物理外用治疗方法，但在疗效和美容效果方面往往不能令人满意。通常广泛发生在面部的疣通常是扁平疣。当发生寻常疣时，通常表现为单发或偶尔多发的皮损，而不是几乎覆盖整个面部。在免疫力低下的情况下，寻常疣会表现出罕见的增殖行为。在本报告中，我们介绍了一名 17 岁的男性青少年，他采用刮除和光动力疗法（PDT）相结合的方法，成功治疗了全身性面部寻常疣。该患者数年来长期使用皮质类固醇激素和他克莫司软膏治疗面部湿疹，这被认为是导致面部皮肤局部免疫抑制状态的重要因素。此外，患者还有痤疮史，面部经常被抓伤。搔抓后出现柯布纳现象被认为是另一个潜在原因。这次治疗完全解决并改善了患者原有的痤疮问题，取得了令人满意的美容效果，在随访期间没有出现任何明显的不良反应或复发。这突出表明，光动力疗法前的刮除术提高了寻常疣的治疗效率，降低了治疗成本。

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Successful Treatment of Generalized Facial Verrucae Vulgaris with a Combination of Curettage and Photodynamic Therapy in an Adolescent: A Case Report

Abstract: Verrucae vulgaris are highly contagious keratotic lesions occurring on the skin caused by human papillomavirus. Generally, verrucae vulgaris are harmless to the body, but when they occur in specific areas such as the face or soles of the feet, they can profoundly impact an individual’s quality of life and necessitate therapeutic intervention. Although several pharmacological and physical topical treatments are available, the results are often unsatisfactory in terms of efficacy and cosmetic outcome. Verrucae which typically occur widely on the face are usually Verrucae Planae. When Verrucae vulgaris does occur, it usually presents as single or occasional multiple lesions, rather than covering almost the entire face. In immunocompromised situations, verruca vulgaris can exhibit rare proliferative behavior. In this report, we present a 17-year-old male adolescent who was successfully treated for generalized facial verrucae vulgaris by using a combination of curettage and photodynamic therapy (PDT). The patient’s prolonged use of topical corticosteroids and tacrolimus ointment on the face for eczema over several years is believed to have led to a localized immunosuppressive state of the facial skin, which is considered a significant factor in the outbreak of verrucae vulgaris. Additionally, the patient has a history of acne and frequently scratched face. The appearance of the Koebner phenomenon following scratching is considered another potential reason. This treatment achieved complete resolution and improved the patient’s pre-existing acne problem, resulting in a satisfactory cosmetic outcome without any notable adverse effects or recurrence during the follow-up period. This highlighted that pre-treatment with curettage before PDT enhanced the efficiency of verrucae vulgaris treatment and reduced the cost.

Keywords: photodynamic therapy, curettage, verruca vulgaris, adolescent, cosmetic

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.