Wen-Juan Li, Shan-He Li, Xue-Yu Man, Gang Xu, Zhen-Lei Zhang, Yao Zhang, Hong Liang, Feng Yang
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A novel Au(III) agent designed to inhibit tumor growth and metastasis through inducing immunogenic cell death
To treat cancer and inhibit its metastasis to the greatest extent, we proposed to develop an Au(III) agent to induce immunogenic cell death (ICD) and establish long-term immunity. To this end, we optimized a series of Au(III) 2-benzoylpyridine thiosemicarbazone complexes to obtain an Au(III) agent (5b) with excellent cytotoxicity to cancer. The results show that 5b effectively inhibits tumor growth and its metastasis in vivo. Interestingly, we revealed a new mechanism of 5b inhibiting tumor growth and metastasis: 5b releases ICD-related damage-associated molecular patterns (DAMPs), such as calreticulin (CRT), ATP and high mobility group box 1 (HMGB1) by inducing endoplasmic reticulum stress (ERS) and mitochondrial dysfunction, which then stimulated an antitumor CD8+ T cell response and Foxp3+ T cell depletion, thus establishing long-action antitumor immunity.
期刊介绍：
Rare Metals is a monthly peer-reviewed journal published by the Nonferrous Metals Society of China. It serves as a platform for engineers and scientists to communicate and disseminate original research articles in the field of rare metals. The journal focuses on a wide range of topics including metallurgy, processing, and determination of rare metals. Additionally, it showcases the application of rare metals in advanced materials such as superconductors, semiconductors, composites, and ceramics.
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