微针:增加透皮给药系统的有效技术。

Sanjit Kr Roy, Kazi Asraf Ali, Mahua Biswas, Abhijit Dey, Amlan Bishal, Abhradeep Kuiry
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引用次数: 0

摘要

透皮给药系统(TDDS)因其控释能力和非侵入性设计而备受关注,被视为传统给药方法的可行替代品。微针是一种新型而有效的技术,最近引起了广泛关注,以进一步提高透皮给药系统的能力。本综述文章全面回顾了微针研究及其改善透皮给药的潜力。研究首先阐明了与传统给药技术相关的困难以及透皮渠道带来的益处。文章随后探讨了微针技术的发展,概述了几种微针--实心、空心和溶解--及其用途。由于微针具有无痛穿透皮肤保护层的特殊能力,并能准确无误地分布药物,因此在药物研究中是一种非常有用的工具。书中对影响微针设计和制造的材料、几何形状和制造工艺进行了批判性分析和介绍。手稿深入探讨了微针技术的最新发展,包括利用可生物降解聚合物、智能材料和传感元件进行即时监测。分析报告最后强调了微针领域值得关注的进展及其改变透皮给药系统的潜力。这些全面的知识旨在推动当前的药物研究讨论,鼓励创新,为创造更安全、更有效的给药系统打开大门。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microneedles: An Efficient Technique to Increase Transdermal Drug Delivery System.

Transdermal Drug Delivery Systems (TDDS) have gained attention as a viable substitute for traditional drug administration methods because of their controlled release capabilities and non-invasive design. Microneedles are a new and effective technology that has attracted a lot of attention recently to enhance the capabilities of TDDS further. The study on microneedles and their potential to improve transdermal medication delivery is thoroughly reviewed in this review article. The study initiates by clarifying the difficulties linked to traditional medication delivery techniques and the benefits provided by transdermal channels. The article then explores the development of microneedle technology, outlining the several kinds of microneedles-solid, hollow, and dissolving-as well as their uses. Because of their special capacity to penetrate the skin's protective layer painlessly and their ability to distribute drugs precisely and precisely, microneedles are a highly useful instrument in pharmaceutical research. The materials, geometry, and manufacturing processes that affect the design and creation of microneedles are critically analyzed and presented. The manuscript delves into the latest developments in microneedle technology, encompassing the utilization of biodegradable polymers, smart materials, and sensing components for in-the-- moment monitoring. This analysis concludes by highlighting the noteworthy advancements in the field of microneedles and their potential to transform transdermal drug delivery systems. This thorough knowledge seeks to further the current discussion in pharmaceutical research, encouraging creativity and opening the door for the creation of safer, more effective drug delivery systems.

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