造血簇的形成：血细胞生成的重要前奏。

IF 2.5 4区医学 Q2 HEMATOLOGY

Experimental hematology Pub Date : 2024-08-01 DOI:10.1016/j.exphem.2024.104284

Tomomasa Yokomizo

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引用次数: 0

摘要

成人血细胞是由造血干细胞（HSC）在骨髓中产生的，其起源可追溯到胎儿发育阶段。事实上，在小鼠发育过程中，妊娠10-11天时，主动脉-性腺-肾上腺（AGM）区域是造血干细胞产生的主要部位，在背侧主动脉可观察到与干细胞生成有关的特征性细胞簇。在卵黄囊和胎盘等其他部位也可观察到与造血相关的类似细胞簇。在这篇综述中，我概述了这些细胞簇的形成和功能，重点是特征明显的主动脉内造血细胞簇（IAHCs）。

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Hematopoietic cluster formation: an essential prelude to blood cell genesis

Adult blood cells are produced in the bone marrow by hematopoietic stem cells (HSCs), the origin of which can be traced back to fetal developmental stages. Indeed, during mouse development, at days 10–11 of gestation, the aorta–gonad–mesonephros (AGM) region is a primary site of HSC production, with characteristic cell clusters related to stem cell genesis observed in the dorsal aorta. Similar clusters linked with hematopoiesis are also observed in the other sites such as the yolk sac and placenta. In this review, I outline the formation and function of these clusters, focusing on the well-characterized intra-aortic hematopoietic clusters (IAHCs).

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来源期刊

Experimental hematology 医学-血液学

CiteScore

5.30

自引率

0.00%

发文量

审稿时长

58 days

期刊介绍： Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.