关于迷幻药物用于成瘾治疗的临床研究和医学化的当前视角：安全性、有效性、局限性和挑战。

IF 7.4 2区医学 Q1 CLINICAL NEUROLOGY

CNS drugs Pub Date : 2024-10-01 Epub Date: 2024-07-20 DOI:10.1007/s40263-024-01101-3

Anton Gomez-Escolar, Daniel Folch-Sanchez, Joanna Stefaniuk, Zoe Swithenbank, Andreia Nisa, Fleur Braddick, Nazish Idrees Chaudhary, Pim B van der Meer, Albert Batalla

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引用次数: 0

摘要

精神疾病，尤其是药物使用障碍（SUDs），是全球疾病负担的重要组成部分。目前，人们正在探索将迷幻剂（包括接触诱导剂和分离物质）用于治疗 SUD，但与抑郁症或创伤后应激障碍（PTSD）等其他精神疾病相比，其临床实践证据较少。在这篇叙述性综述中，我们讨论了迷幻药、麦角酰二乙胺（LSD）、氯胺酮、3,4-亚甲二氧基甲基苯丙胺（MDMA）和伊博卡因目前的临床研究证据、治疗潜力和安全性，尤其是在治疗 SUD 方面。我们的目的是均衡地概述目前关于迷幻药在治疗精神分裂症的临床环境中的潜在益处和危害的研究和发现。我们强调了在这一特定治疗领域开展更多临床研究的必要性，并指出了未来研究中需要解决的一些局限性和挑战。

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Current Perspectives on the Clinical Research and Medicalization of Psychedelic Drugs for Addiction Treatments: Safety, Efficacy, Limitations and Challenges.

Mental health disorders and substance use disorders (SUDs) in particular, contribute greatly to the global burden of disease. Psychedelics, including entactogens and dissociative substances, are currently being explored for the treatment of SUDs, yet with less empirical clinical evidence than for other mental health disorders, such as depression or post-traumatic stress disorder (PTSD). In this narrative review, we discuss the current clinical research evidence, therapeutic potential and safety of psilocybin, lysergic acid diethylamide (LSD), ketamine, 3,4-methylenedioxymethamphetamine (MDMA) and ibogaine, particularly in the context of the SUD treatment. Our aim was to provide a balanced overview of the current research and findings on potential benefits and harms of psychedelics in clinical settings for SUD treatment. We highlight the need for more clinical research in this particular treatment area and point out some limitations and challenges to be addressed in future research.

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来源期刊

CNS drugs 医学-精神病学

CiteScore

12.00

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： CNS Drugs promotes rational pharmacotherapy within the disciplines of clinical psychiatry and neurology. The Journal includes: - Overviews of contentious or emerging issues. - Comprehensive narrative reviews that provide an authoritative source of information on pharmacological approaches to managing neurological and psychiatric illnesses. - Systematic reviews that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. - Adis Drug Reviews of the properties and place in therapy of both newer and established drugs in neurology and psychiatry. - Original research articles reporting the results of well-designed studies with a strong link to clinical practice, such as clinical pharmacodynamic and pharmacokinetic studies, clinical trials, meta-analyses, outcomes research, and pharmacoeconomic and pharmacoepidemiological studies. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in CNS Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.