胚胎植入前发育过程中的端粒伸长

4区生物学 Q3 Medicine

Advances in Anatomy Embryology and Cell Biology Pub Date : 2024-01-01 DOI:10.1007/978-3-031-55163-5_6

Hyuk-Joon Jeon, Mia T Levine, Michael A Lampson

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引用次数: 0

摘要

哺乳动物端粒延长的主要机制是端粒酶的逆转录。在一些癌细胞中和胚胎植入前的发育过程中，端粒长度会在几个细胞周期内迅速增加，而另一种（ALT）途径则通过同源重组来延长端粒。子代中的母端粒和父端粒在遗传学和表观遗传学上是不同的，端粒长度和染色质包装也不同。我们讨论了这些不对称性如何在最早的胚胎细胞周期中促进端粒调控的模型，并提出了未来的研究方向。

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Telomere Elongation During Pre-Implantation Embryo Development.

The primary mechanism of telomere elongation in mammals is reverse transcription by telomerase. An alternative (ALT) pathway elongates telomeres by homologous recombination in some cancer cells and during pre-implantation embryo development, when telomere length increases rapidly within a few cell cycles. The maternal and paternal telomeres in the zygote are genetically and epigenetically distinct, with differences in telomere length and in chromatin packaging. We discuss models for how these asymmetries may contribute to telomere regulation during the earliest embryonic cell cycles and suggest directions for future research.

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来源期刊

Advances in Anatomy Embryology and Cell Biology 生物-发育生物学

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： "Advances in Anatomy, Embryology and Cell Biology" presents critical reviews on all topical fields of normal and experimental anatomy including cell biology. The multi-perspective presentation of morphological aspects of basic biological phenomen in the human constitutes the main focus of the series. The contributions re-evaluate the latest findings and show ways for further research.