转录因子依赖性确定了 BAF 依赖性癌症

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-07-18 DOI:10.1016/j.ccell.2024.06.013

引用次数: 0

摘要

在《癌症细胞》（Cancer Cell）杂志上，Bolomsky 等人、Duplaquet 等人和 He 等人发现了依赖 BAF 染色质重塑复合物的癌症，特别是 IRF4 驱动的多发性骨髓瘤和 POU2F3 亚型小细胞肺癌，突出了 BAF 复合物抑制剂/降解剂的潜在治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transcription factor dependencies identify BAF-dependent cancers

In Cancer Cell, Bolomsky et al., Duplaquet et al., and He et al. identify cancers that are dependent on the BAF chromatin remodeling complex, specifically IRF4-driven multiple myeloma and POU2F3-subtype small cell lung cancer, highlighting potential therapeutic applications for BAF complex inhibitors/degraders.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.