[CGRP：从神经肽到治疗目标（背景和病理生理学）]。

IF 0.6 4区医学 Q4 CLINICAL NEUROLOGY

Fortschritte Der Neurologie Psychiatrie Pub Date : 2024-07-01 Epub Date: 2024-07-18 DOI:10.1055/a-2331-0783

Katharina Kamm

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引用次数: 0

摘要

降钙素基因相关肽（CGRP）在偏头痛的病理生理学中起着举足轻重的作用。大量临床研究调查了偏头痛发作间期和发作期的降钙素相关肽水平，并报道了基于降钙素相关肽的偏头痛疗法的疗效，由此可见降钙素相关肽在偏头痛中的重要性。本文将介绍上述研究，并向读者介绍基于CGRP的药物开发。最后，还将介绍目前关于CGRP受体拮抗剂（即所谓的 "gepants"）的研究成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[CGRP: from neuropeptide to the therapeutic target (background and pathophysiology)].

Calcitonin gene-related peptide (CGRP) plays a pivotal role in migraine pathophysiology. The importance of CGRP in migraine became evident from numerous clinical studies investigating CGRP levels both interictally and ictally and reports on the efficacy of CGRP-based migraine therapies. In this paper, the above mentioned studies will be presented and the reader will be introduced to the development of CGRP-based medication. Finally, current study results on CGRP receptor antagonists, the so-called gepants, will be presented.

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来源期刊

Fortschritte Der Neurologie Psychiatrie 医学-精神病学

CiteScore

1.10

自引率

16.70%

发文量

139

审稿时长

6-12 weeks

期刊介绍： Fundiertes Wissen für den Berufsalltag Relevante Originalarbeiten Informative Übersichten zu wichtigen Themen Fortbildungsteil mit Zertifizierung – 36 CME-Punkte pro Jahr Interessante Kasuistiken Referiert & kommentiert: Internationale Studien Aktuelles zu Begutachtung und Neurobiologie International gelistet und häufig zitiert