稳定肠道屏障的完整性，控制关节炎。

IF 4.9 2区医学 Q1 Medicine

Arthritis Research & Therapy Pub Date : 2024-07-18 DOI:10.1186/s13075-024-03378-7

George D Kalliolias, Athanasios G Papavassiliou

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引用次数: 0

摘要

我们饶有兴趣地阅读了 Lyu 等人最近发表在《风湿病年鉴》上的文章《肠上皮细胞中 HIF1α 的表达通过抑制 RIPK3 诱导的细胞死亡机制限制了关节炎炎症》。作者认为，低氧诱导因子1α在肠上皮细胞中的表达阻碍了肠上皮细胞的坏死，保护了肠屏障的完整性，是关节炎发展的一个关键检查点。以往的研究表明，肠屏障功能缺陷与致关节炎免疫细胞的增效之间存在潜在的机制联系。从这个角度来看，加强肠道屏障的完整性是治疗类风湿性关节炎的一种有吸引力的策略。

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Stabilizing the integrity of intestinal barrier to control arthritis.

With great interest, we have read the recent article "Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery" published by Lyu et al. in Annals of the Rheumatic Diseases. The authors pose that the expression of hypoxia-inducible factor 1 alpha in intestinal epithelial cells represents a crucial check point for the development of arthritis by impeding necroptosis of intestinal epithelial cells and safeguarding the intestinal barrier integrity. Previous studies suggest a potential mechanistic link between faulty intestinal barrier function and potentiation of arthritogenic immune cells. From this perspective, bolstering the intestinal barrier integrity arose as an attractive therapeutic strategy for rheumatoid arthritis.

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来源期刊

Arthritis Research & Therapy RHEUMATOLOGY-

CiteScore

8.60

自引率

2.00%

发文量

261

审稿时长

14 weeks

期刊介绍： Established in 1999, Arthritis Research and Therapy is an international, open access, peer-reviewed journal, publishing original articles in the area of musculoskeletal research and therapy as well as, reviews, commentaries and reports. A major focus of the journal is on the immunologic processes leading to inflammation, damage and repair as they relate to autoimmune rheumatic and musculoskeletal conditions, and which inform the translation of this knowledge into advances in clinical care. Original basic, translational and clinical research is considered for publication along with results of early and late phase therapeutic trials, especially as they pertain to the underpinning science that informs clinical observations in interventional studies.