使用同心针电极进行抖动分析,评估重症肌无力患者的疾病状态和治疗反应

IF 2 Q3 NEUROSCIENCES
Vinaya Bhandari, Ajith Sivadasan, Carolina Barnett-Tapia, Hans Katzberg, Vera Bril
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引用次数: 0

摘要

目的本研究评估了用同心针抖动分析评估重症肌无力(MG)疾病严重程度、抖动变化与临床状态之间的相关性以及确定任何不一致的原因的实用性。方法我们对82名MG患者进行了回顾性病历审查,并提取了基线和随访时的人口统计学、MG亚型、抗体状态、临床量表、电生理学和干预措施等数据。结果基线MGII评分与抖动(r = 0.25,p = 0.024)和异常配对(r = 0.24,p = 0.03)相关。28 个月后,MGII 分数与抖动(r = 0.31,p = 0.006)、异常配对(r = 0.29,p = 0.009)和有区块的配对(r = 0.35,p = 0.001)相关。MGII评分的变化与抖动(r = 0.35,p = 0.002)、异常配对(r = 0.27,p = 0.014)和带阻滞配对(r = 0.36,p = 0.001)的变化相关。本研究强调了通过使用同心针抖动分析进行精确评估和管理来提高 MG 诊断和疾病活动监测的准确性,从而改善 MG 患者护理的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Using jitter analysis with concentric needle electrodes to assess disease status and treatment responses in myasthenia gravis

Objective

This study assesses the utility of jitter analysis with concentric needles to evaluate disease severity in myasthenia gravis (MG), correlate changes in jitter with clinical status as well as identify reasons for any discordance.

Methods

We performed a retrospective chart review of 82 MG patients and extracted data on demographics, MG subtype, antibody status, clinical scales, electrophysiology, and interventions at baseline and follow-up.

Results

Baseline MGII scores correlated with jitter (r = 0.25, p = 0.024) and abnormal pairs (r = 0.24, p = 0.03). After 28 months, MGII scores correlated with jitter (r = 0.31, p = 0.006), abnormal pairs (r = 0.29, p = 0.009), and pairs with blocks (r = 0.35, p = 0.001). Changes in MGII scores correlated with changes in jitter (r = 0.35, p = 0.002), abnormal pairs (r = 0.27, p = 0.014), and pairs with blocks (r = 0.36, p = 0.001).

Conclusions

Concentric needle jitter analysis may have the potential to evaluate baseline and sequential disease severity in MG.

Significance

This study highlights the potential for improved MG patient care through precise assessment and management using concentric needle jitter analysis to improve the accuracy of MG diagnosis and monitoring of disease activity.

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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
47
审稿时长
71 days
期刊介绍: Clinical Neurophysiology Practice (CNP) is a new Open Access journal that focuses on clinical practice issues in clinical neurophysiology including relevant new research, case reports or clinical series, normal values and didactic reviews. It is an official journal of the International Federation of Clinical Neurophysiology and complements Clinical Neurophysiology which focuses on innovative research in the specialty. It has a role in supporting established clinical practice, and an educational role for trainees, technicians and practitioners.
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