从患者身上分离出的阴道念珠菌对 Parameria laevigata (Juss.) Moldenke 茎皮乙醇提取物的作用机制和抗真菌活性

Q3 Pharmacology, Toxicology and Pharmaceutics

Pharmacognosy Journal Pub Date : 2024-07-01 DOI:10.5530/pj.2024.16.109

Wirda Anggraini, Djoko Agus Purwanto, Idha Kusumawati, Isnaeni Isnaeni

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引用次数: 0

摘要

目前的抗生素耐药性情况。抗菌药物管理计划和药物高筛选是其中的两项措施。如今，真菌感染已成为严重的健康问题。利用对各种人类致病真菌有效的植物性天然化合物是预防真菌感染相关问题的一种方法。在这项研究中，提取物被用作治疗白色念珠菌感染患者的一种选择。该研究旨在检测从 Parameria laevigata (Juss.) Moldenke 茎皮中提取的乙醇提取物对从患者体内分离出的白色念珠菌的抗真菌特性。研究方法本研究采用微量稀释法。从确诊为外阴阴道念珠菌病的患者体内分离出白念珠菌。测试样品为从月见草茎皮中提取的 70% 和 96% 的乙醇。数据分析采用单因素方差分析，P 值为 0.000。结果显示结果表明，PLE-70 可抑制白僵菌的生长，对 ATCC 14053、CP-1、CP-2、CP-3 和 CP-4 的抑制率最高，分别为 36.39%、37.51%、38.66%、45.78% 和 84.87%。PLE-96 可抑制白僵菌的生长，对 ATCC 14053、CP-1、CP-2、CP-3 和 CP-4 的抑制率最高，分别为 17.49%；17.77%；29.27%；34.12%；38.42%。结论结论：茎皮中的乙醇提取物可抑制从外阴阴道念珠菌病患者中分离出的白色念珠菌。

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Mechanism and Antifungal Activities Vulvovaginal Candidiasis Isolated from Patients Against Ethanol Extracts of Parameria laevigata (Juss.) Moldenke Stem Bark

current antibiotic resistance situation. Antimicrobial stewardship programs and high drug screening are two of the measures that are being used. Today, fungal infections are severe health problems. Utilizing plant-based natural compounds that are effective against various human pathogenic fungi is one method for preventing the issues associated with fungal infection. In this research, extracts are used as an option to treat patients with Candida albicans infection. The research aimed to examine the antifungal properties of an ethanol extract from Parameria laevigata (Juss.) Moldenke stem bark against C. albicans isolated from patients. Methods: This research used a microdilution method. C. albicans from patients diagnosed with vulvovaginal candidiasis. The test sample is 70% and 96% ethanol extracted from P. laevigata stem bark. Data analysis used One-way ANOVA with a P value of 0.000. Results: The result showed that PLE-70 can inhibit the growth of C. albicans with the highest %inhibition for ATCC 14053, CP-1, CP-2, CP-3, and CP-4, respectively 36.39%; 37.51%; 38.66%; 45.78%; 84.87%. PLE-96 can inhibit the growth of C. albicans with the highest %inhibition for ATCC 14053, CP-1, CP-2, CP-3, and CP-4 respectively 17.49%; 17.77%; 29.27%; 34.12%; 38.42%. Conclusion: It was concluded that the ethanol extract from P. laevigata stem bark can inhibit C. albicans isolated from vulvovaginal candidiasis patients

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来源期刊

Pharmacognosy Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

2.20

自引率

0.00%

发文量

151

期刊介绍： In 2004, as the PHCOG.NET – a non-profit private organization dedicated to Natural Products Research leading to develop promising drugs. Our main mission is to make information on herbal drug research readily available in different formats to suit the individual needs. Pharmacognosy Journal (Phcog J.) is one of the six journals published by Phcog.Net, Each issue covers different topics in natural product drug discovery, and also publishes manuscripts that describe pharmacognostic investigations, evaluation reports, methods, techniques and applications of all forms of medicinal plant research