小胶质细胞通过 ATP-AMP-ADO 通路协调围手术期神经认知障碍的脑淋巴系统清除工作

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-07-10 DOI:10.1016/j.mehy.2024.111430

Yongfeng Zheng , Daoyun Lei

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引用次数: 0

摘要

围手术期神经认知障碍（PND）是一种认知功能障碍，通常发生在手术后，尤其是老年患者。脑淋巴系统是神经系统的免疫清道夫，可能在 PND 的发生中起着至关重要的作用。最近的研究表明，小胶质细胞通过感知三磷酸腺苷（ATP）的代谢产物，抑制神经元的电活动。这种抑制可能会影响大脑淋巴系统的驱动力，并损害其清除功能。研究小胶质细胞在通过 ATP-AMP（单磷酸腺苷）-ADO（腺苷）途径调节脑淋巴系统中的作用，可为 PND 的发病机制提供新的见解，并为其预防和治疗找到新的靶点和策略。

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Microglia harmonize the cerebral lymphoid system clearance in perioperative neurocognitive disorders by the ATP-AMP-ADO pathway

Perioperative neurocognitive disorder (PND) is a cognitive dysfunction that often occurs after surgery, particularly in elderly patients. The cerebral lymphatic system, which acts as an immune scavenger for the nervous system, may play a crucial role in the development of PND. Recent studies suggest that microglia, by sensing metabolites of ATP (adenosine triphosphate), inhibit neuronal electrical activity. This inhibition may impact the driving force of the cerebral lymphatic system and impair its scavenging function. Investigating the role of microglia in regulating the cerebral lymphatic system through the ATP-AMP (adenosine monophosphate)-ADO (adenosine) pathway could provide new insights into the pathogenesis of PND and identify novel targets and strategies for its prevention and treatment.

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.