股骨头坏死的保守治疗:系统性综述

E. Goncharov, O. Koval, Eduard Nikolaevich Bezuglov, Aleksandr Aleksandrovich Vetoshkin, Nikolay Gavriilovich Goncharov, M.J. Encarnacion Ramirez, N. Montemurro
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摘要

导言:股骨头血管性坏死(AVN)是一个紧迫的骨科问题,会因血液供应中断而导致骨组织坏死,严重影响患者的生活质量。本综述侧重于保守疗法,评估其作为主要疗法的疗效。对 AVN 病理生理学的深入了解和诊断工具的进步重新点燃了人们对非手术干预的兴趣,强调通过个性化、多学科的方法来改善治疗效果。材料与方法:自 2020 年 1 月至 2023 年 8 月,在 PubMed、SCOPUS 和 Google Scholar 数据库中进行了系统性检索,目的是关注股骨头坏死的保守疗法。符合条件的研究包括原创性研究、病例报告和观察性研究,对保守治疗后相关的、有充分证据证明的患者疗效进行了审查,排除了非英语文章和以手术为重点但没有比较保守治疗数据的文章。结果:通过系统检索,在多个数据库中找到了376条有关股骨头坏死的记录。经过去重和严格的相关性和质量筛选,最终纳入了 11 篇全文文章进行全面的定性综合,重点关注保守治疗。结论:本综述评估了药物干预和物理疗法等保守疗法在治疗股骨头坏死方面的有效性。尽管在缓解症状和延缓疾病进展方面取得了可喜的成果,但由于结果的多变性和研究方法上的局限性,有必要进一步开展严格的随机对照试验,以便采用稳健的、以患者为中心的方法来优化 AVN 的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Conservative Treatment in Avascular Necrosis of the Femoral Head: A Systematic Review
Introduction: Avascular necrosis (AVN) of the femoral head is a pressing orthopedic issue, leading to bone tissue death due to disrupted blood supply and affecting the quality of life of individuals significantly. This review focuses on conservative treatments, evaluating their efficacy as mainstay therapies. Enhanced understanding of AVN’s pathophysiology and advancements in diagnostic tools have rekindled interest in non-surgical interventions, emphasizing personalized, multidisciplinary approaches for improved outcomes. Material and Method: A systematic search was conducted on PubMed, SCOPUS, and Google Scholar databases from January 2020 to August 2023, with the objective of focusing on conservative treatments for AVN of the femoral head. Eligible studies, including original research, case reports, and observational studies, were examined for relevant, well-documented patient outcomes post-conservative treatments, excluding non-English and surgically focused articles without comparative conservative data. Results: A systematic search yielded 376 records on AVN of the femoral head across multiple databases. After de-duplication and rigorous screening for relevance and quality, 11 full-text articles were ultimately included for a comprehensive qualitative synthesis, focusing on conservatively managing the condition. Conclusions: This review evaluates the effectiveness of conservative treatments such as pharmacological interventions and physical modalities in managing AVN of the femoral head. Despite promising results in symptom alleviation and disease progression delay, variability in outcomes and methodological limitations in studies necessitate further rigorous, randomized controlled trials for a robust, patient-centric approach to optimize therapeutic outcomes in AVN management.
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