Kele叶(Brasica oleracea var. sabellica)乙醇提取物对阿脲诱导雄性大鼠(Rattus norvegicus)丙二醛水平、血糖谱、SGOT和SGPT的影响

Putu Ari Wijanadipa, A. A. S. A. Sukmaningsih, Ni Putu Adriani Astiti
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引用次数: 0

摘要

糖尿病(DM)是一种代谢性疾病,其特征是由于缺乏胰岛素或胰岛素抵抗引起的高血糖。本研究旨在确定甘蓝叶提取物对阿脲诱导的血糖水平、SGOT、SGPT、MDA 和大鼠肝组织学的影响。本研究使用了体重为 200-300 克的 3 个月大的成年大鼠。采用的研究设计是完全随机设计(CRD),包括 5 个处理,每个处理有 5 次重复。五个处理包括作为阴性对照的 K-(给予 0.2 毫升氯化钠)、作为阳性对照的 K+(给予阿脲剂量 120 毫克/千克体重)、P1(给予阿脲剂量 120 毫克/千克体重和甘蓝叶提取物 250 毫克/千克体重)、P2(给予阿脲剂量 120 毫克/千克体重和甘蓝叶提取物 500 毫克/千克体重)和 P3(给予阿脲剂量 120 毫克/千克体重和甘蓝叶提取物 1000 毫克/千克体重)。雄性大鼠的疗程为 28 天。此外,还检查了血糖水平、SGOT、SGPT 和 MDA。结果表明,羽衣甘蓝叶乙醇提取物的剂量为 1000 毫克/千克体重,在降低丙二醛 (MDA)、血糖水平、SGOT、SGPT 和肝脏水平方面最有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efektivitas Ekstrak Etanol Daun Kele (Brasica oleracea var. sabellica) Terhadap Kadar Malondialdehide, Profil Gula Darah, SGOT, dan SGPT Tikus (Rattus norvegicus) Jantan Yang Diinduksi Aloksan
Diabetes Mellitus (DM) is a metabolic disease characterized by hyperglycemia due to a lack of insulin or caused by insulin resistance. The aim of this study was to determine the effectiveness of kale leaf extract on blood sugar levels, SGOT, SGPT, MDA, and rat liver histology induced by alloxan. This study used 3 months old adult rats weighing 200-300 grams. The research design used was a Completely Randomized Design (CRD) consisting of 5 treatments and for each treatment, there were 5 replications. Five treatments consisted of K- as a negative control (given 0.2 ml NaCl), K + as a positive control (given alloxan dose 120 mg / kg BW), P1 (given alloxan dose 120 mg / kg BW and kale leaf extract 250 mg / kg BW), P2 (given alloxan dose of 120 mg / kg BW and 500 mg / kg BW of kale leaf extract) and P3 (given alloxan dose of 120 mg / kg BW and kale leaf extract of 1000 mg / kg BW). The treatment given to male rats was carried out for 28 days. Furthermore, checking blood sugar levels, SGOT, SGPT, and MDA The data obtained were analyzed using the SPSS 15.0 program. The results showed that giving kale leaf ethanol extract at a dose of 1000 mg/kg BW was the most effective in reducing levels of Malondialdehyde (MDA), blood sugar levels, SGOT, SGPT, and liver in alloxan-i  
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