Could hydrogen gas be produced using human cells?

Although fossil fuels are widely used to meet energy needs, intensive research has been carried out in recent years on hydrogen production from renewable sources due to their decrease over time and environmental pollution concerns. Biofuel cell technology is one of the promising current technologies. It has been proven that various microorganisms produce energy through their natural metabolism, and that energy production is produced in biofuel cells by exoelectrogenic microorganisms that can transfer electrons to an electrode surface. Although it has been stated that employing human cells to generate energy is feasible, it is unknown whether doing so would enable the production of hydrogen. Within the scope of this perspective article, the issue of hydrogen production in bioelectrolysis cells using human cells will be discussed for the first time. Optimizing hydrogen production in bioelectrolysis cells using human cells is important in terms of contributing to hydrogen technologies. Within the scope of the article, promising human cell lines for hydrogen production are emphasized and hydrogen production potentials in bioelectrolysis cells using these cell lines are discussed. In conclusion, some human cells can be used for hydrogen gas production in bioelectrolysis cells due to their bioelectrochemical and metabolic properties.