AMPA 受体在社会行为中的作用

IF 2.8 4区 医学 Q2 NEUROSCIENCES
Qi Wei Xu, Amanda Larosa, Tak Pan Wong
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引用次数: 0

摘要

作为兴奋性突触传递的关键角色,AMPA 受体(AMPARs)有助于社会行为的形成、调节和表达。AMPAR 的改变与自然社会行为(如攻击性、交际能力和社会记忆)有关,但在以社会行为受损为特征的脑部疾病中也很常见。了解 AMPARs 在社交行为中的作用对于揭示治疗自闭症谱系障碍和精神分裂症等疾病中社交障碍的治疗靶点非常及时。在这篇综述中,我们将讨论 AMPARs 的分子组成、功能和可塑性对社会行为的贡献。我们还将讨论针对 AMPARs 治疗脑部疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Roles of AMPA receptors in social behaviors
As a crucial player in excitatory synaptic transmission, AMPA receptors (AMPARs) contribute to the formation, regulation, and expression of social behaviors. AMPAR modifications have been associated with naturalistic social behaviors, such as aggression, sociability, and social memory, but are also noted in brain diseases featuring impaired social behavior. Understanding the role of AMPARs in social behaviors is timely to reveal therapeutic targets for treating social impairment in disorders, such as autism spectrum disorder and schizophrenia. In this review, we will discuss the contribution of the molecular composition, function, and plasticity of AMPARs to social behaviors. The impact of targeting AMPARs in treating brain disorders will also be discussed.
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来源期刊
CiteScore
7.10
自引率
2.70%
发文量
74
审稿时长
14 weeks
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