[路易体痴呆症和阿尔茨海默病患者功能衰退的比较]。

IF 0.4 4区 医学 Q4 PSYCHIATRY
Audrey Rouet, Vincenzo Autieri, Bénédicte Dieudonné, Sandrine Greffard, Zina Barrou, Charlotte Tomeo, Rebecca Haddad, Judith Cohen-Bittan, Jacques Boddaert, Bastien Genet, Marc Verny
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引用次数: 0

摘要

路易体痴呆(LBD)是仅次于阿尔茨海默病(AD)的第二大神经退行性疾病。在这项研究中,我们比较了路易体痴呆患者和阿尔茨海默病患者在 18 个月随访期内的功能衰退情况,并考虑了运动功能障碍。我们纳入了所有年龄大于 70 岁、初始 MMSE ≥ 20 且诊断为可能或疑似枸杞多糖症或阿兹海默症的患者,他们都曾在 Pitié-Salpêtrière 医院的记忆中心就诊。统计分析采用单变量检验和多变量线性回归法。37名AD患者和36名LBD患者的年龄中位数为81岁,MMSE评分中位数为24/30。与AD患者相比,LBD患者的总体ADL Katz评分明显下降:-0.40±0.75对0±0.24;P=0.003。两种人群的总体 IADL 得分均有所下降,但两组之间无明显差异:LBD 患者为 -1.71 ± 2.19,而 AD 患者为 -1.32 (± 1.55);P=0.38。这项研究表明,随着时间的推移,肢体残疾患者的自理能力明显下降,下降速度快于注意力缺失症患者,尤其是在洗澡、穿衣和个人护理方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Comparaison du déclin fonctionnel entre des patients atteints de démence à corps de Lewy et de la maladie d'Alzheimer].

Lewy body dementia (LBD) is the second most frequent neurodegenerative disorder after Alzheimer disease (AD). In this study, we compared functional decline between LBD and AD patients, considering motor dysfunction, over an 18-month follow-up period. We included all patients >70 years of age, with initial MMSE ≥ 20 and a diagnosis of possible or probable LBD or AD, who consulted at the memory centre of the Pitié-Salpêtrière hospital. Statistical analyses were performed using univariate tests and multivariate linear regression. Thirty-seven AD and 36 LBD patients were included, with a median age of 81 and a median MMSE score of 24/30. Global ADL Katz score decreased significantly for LBD people, compared to AD patients: -0.40 ± 0.75 versus 0 ± 0.24; p=0.003. Global IADL score decreased in the two populations but without a significant difference between the two groups: -1.71 ± 2.19 in LBD versus -1.32 (± 1.55); p=0.38. This study shows a significant decrease in autonomy in LBD patients over time that was faster than that in AD patients, related, in particular, to bathing, dressing and personal care.

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来源期刊
CiteScore
0.70
自引率
16.70%
发文量
0
审稿时长
6-12 weeks
期刊介绍: D''une qualité scientifique reconnue cette revue est, la première revue francophone gériatrique et psychologique indexée dans les principales bases de données internationales. Elle couvre tous les aspects médicaux, psychologiques, sanitaires et sociaux liés au suivi et à la prise en charge de la personne âgée. Que vous soyez psychologues, neurologues, psychiatres, gériatres, gérontologues,... vous trouverez à travers cette approche originale et unique, un veritable outil de formation, de réflexion et d''échanges indispensable à votre pratique professionnelle.
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