缺血性中风与自噬：长非编码 RNA 的作用

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-01-01 DOI:10.2174/1570159X22666240704123701

Longqiang Ouyang, Wenyan Xia, Ameen Abdulhasan Al-Alwany, Reena Gupta, Ibrokhim Sapaev, Sami G Almalki, Saud Almawash, Rand Ali Ziyad, Ahmed Hussien Alawadi, Ali Alsalamy

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引用次数: 0

摘要

缺血性中风是全球发病率和死亡率的重要原因。自噬是一种细胞内降解过程，已被证明在缺血性中风的发病机制中起着至关重要的作用。长非编码 RNA（lncRNA）已成为包括缺血性中风在内的各种疾病中自噬的重要调节因子。最近的研究发现了几种能调节缺血性脑卒中自噬的 lncRNA，包括 MALAT1、MIAT、SNHG12、H19、AC136007.2、C2dat2、MEG3、KCNQ1OT1、SNHG3 和 RMRP。这些 lncRNA 通过与参与自噬过程的关键蛋白（如 Beclin-1、ATG7 和 LC3）相互作用来调控自噬。了解lncRNAs在缺血性脑卒中自噬调控中的作用，可为该病的发病机制提供新的见解，并确定潜在的治疗靶点。

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Ischemic Stroke and Autophagy: The Roles of Long Non-Coding RNAs.

Ischemic stroke is a significant cause of morbidity and mortality worldwide. Autophagy, a process of intracellular degradation, has been shown to play a crucial role in the pathogenesis of ischemic stroke. Long non-coding RNAs (lncRNAs) have emerged as essential regulators of autophagy in various diseases, including ischemic stroke. Recent studies have identified several lncRNAs that modulate autophagy in ischemic stroke, including MALAT1, MIAT, SNHG12, H19, AC136007. 2, C2dat2, MEG3, KCNQ1OT1, SNHG3, and RMRP. These lncRNAs regulate autophagy by interacting with key proteins involved in the autophagic process, such as Beclin-1, ATG7, and LC3. Understanding the role of lncRNAs in regulating autophagy in ischemic stroke may provide new insights into the pathogenesis of this disease and identify potential therapeutic targets for its treatment.

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.