非同寻常的天然 HIV-1 控制：洞察功能性疗法

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-09-13 Epub Date: 2024-07-15 DOI:10.1016/j.medj.2024.06.008

María Salgado, Stephen A Migueles, Xu G Yu, Javier Martinez-Picado

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引用次数: 0

摘要

特殊精英控制者是一群极其罕见的 HIV-1 感染者（PWH），他们自发地将病毒复制控制在敏感的临床监测化验的检测极限以下，并且在没有抗逆转录病毒治疗的情况下长期（通常超过 25 年）不出现疾病进展。在此，我们将讨论科学文献中报道的不同病例、其独特的遗传学、病毒学和免疫学特征，以及他们作为功能性治愈 HIV-1 的最佳模型的相关性。

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Exceptional, naturally occurring HIV-1 control: Insight into a functional cure.

Exceptional elite controllers represent an extremely rare group of people with HIV-1 (PWH) who exhibit spontaneous, high-level control of viral replication below the limits of detection in sensitive clinical monitoring assays and without disease progression in the absence of antiretroviral therapy for prolonged periods, frequently exceeding 25 years. Here, we discuss the different cases that have been reported in the scientific literature, their unique genetic, virological, and immunological characteristics, and their relevance as the best model for the functional cure of HIV-1.

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.