Vinicius Guzzoni, Isabel Cristina Mallosto Emerich de Abreu, Mariane Bertagnolli, Roberta Hack Mendes, Adriane Belló-Klein, Dulce Elena Casarini, Karin Flues, Geórgia Orsi Cândido, Janaína Paulini, Kátia De Angelis, Fernanda Klein Marcondes, Maria Cláudia Irigoyen, Tatiana Sousa Cunha
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引用次数: 0
摘要
研究目的研究目的：探讨有氧训练对高血压和糖尿病（SHR-STZ）大鼠肾功能、氧化应激、肾内肾素-血管紧张素系统和死亡率的影响：材料和方法：训练后的 SHR-STZ 大鼠的血压、肌酐、尿素水平、尿糖、尿量和蛋白质排泄量均有所降低：结果：有氧训练不仅减轻了氧化应激，还提高了SHR-STZ大鼠肾脏中抗氧化酶的活性。训练提高了肾脏内血管紧张素转换酶（ACE和ACE2）的水平以及肾酶（NEP）的活性，同时降低了肾脏内血管紧张素II（Ang II）的水平。有氧训练明显提高了 STZ-SHR 大鼠的存活率：结论：有氧训练的保护作用与肾脏抗氧化能力的提高、尿蛋白排泄量的减少以及肾内血管紧张素 II 水平的降低和 NEP 活性的提高有关。这些发现可能反映了在高血压和糖尿病的综合病理条件下，大鼠的存活率更高。
Aerobic training increases renal antioxidant defence and reduces angiotensin II levels, mitigating the high mortality in SHR-STZ model.
Objectve: The purpose of the research was to investigate the effects of aerobic training on renal function, oxidative stress, intrarenal renin-angiotensin system, and mortality of hypertensive and diabetic (SHR-STZ) rats.
Materials and methods: Blood pressure, creatinine, urea levels, urinary glucose, urine volume, and protein excretion were reduced in trained SHR-STZ rats.
Results: Aerobic training not only attenuated oxidative stress but also elevated the activity of antioxidant enzymes in the kid'ney of SHR-STZ rats. Training increased intrarenal levels of angiotensin-converting enzymes (ACE and ACE2) as well as the neprilysin (NEP) activity, along with decreased intrarenal angiotensin II (Ang II) levels. Aerobic training significantly improved the survival of STZ-SHR rats.
Conclusion: The protective role of aerobic training was associated with improvements in the renal antioxidative capacity, reduced urinary protein excretion along with reduced intrarenal Ang II and increased NEP activity. These findings might reflect a better survival under the combined pathological conditions, hypertension, and diabetes.
期刊介绍：
Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders.
The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications.
Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics:
-Dysregulation of hormone receptors and signal transduction
-Contribution of gene variants and gene regulatory processes
-Impairment of intermediary metabolism at the cellular level
-Secretion and metabolism of peptides and other factors that mediate cellular crosstalk
-Therapeutic strategies for managing metabolic diseases
Special issues dedicated to topics in the field will be published regularly.
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