Cramer J Kallem, Alaa A Alghwiri, Jonathan G Yabes, Maria-Eleni Roumelioti, Sarah Erickson, Bruce L Rollman, Steven Weisbord, Mark Unruh, Yoram Vodovotz, Manisha Jhamb, Jennifer L Steel
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引用次数: 0
摘要
背景:在许多慢性疾病中,患者报告的症状与炎症生物标志物有关。我们研究了终末期肾病(ESKD)患者的炎症生物标志物与疼痛、疲劳和抑郁的关系,以及技术辅助分步协作护理(TĀCcare)干预对这些生物标志物的影响:在TĀCcare多站点随机对照试验中,收集了基线、3个月和6个月时患者报告的症状数据。对抗炎性[白细胞介素 1 受体激动剂(IL-1RA)、IL-10]、促炎性[肿瘤坏死因子α(TNF-α)、高敏 C 反应蛋白(hs-CRP)、IL-6]和调节性[IL-2]生物标志物进行了检测。在对年龄、性别、种族和合并症进行调整后,采用线性混合效应模型来检验组内和组间差异:在160名患者(平均年龄58±14岁,55%为男性,52%为白人)中,炎症生物标志物与基线时的疼痛、疲劳或抑郁之间没有明显关联。干预组和对照组的IL-10和IL-1RA在6个月内均有下降(β范围=-1.22至-0.40,P范围=结论:TĀCcare干预对减轻ESKD患者的炎症负担有短期影响。还需要更多的研究来证实我们的发现,并确定这些生物标志物是否介导了症状和疾病进展之间的联系。