预测不明原因不孕症患者体外受精-胚胎移植后妊娠结局的受精前参数。

IF 3.3 4区 医学 Q1 Medicine
A C Ozturk, B Dilbaz, R Ozelci, S Dilbaz
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引用次数: 0

摘要

目的:辅助生殖技术(ART)被认为是治疗不明原因不孕症最有效的方法。本研究旨在调查因不明原因不孕而接受体外受精-胚胎移植(IVF-ET)治疗的妇女的妊娠结局以及影响这些结局的因素:本研究纳入了2007年1月至2019年12月期间在安卡拉Etlik Zübeyde Hanım妇科培训与研究医院健康科学大学ART诊所接受体外受精-胚胎移植治疗的789名不明原因不孕症女性。对影响这些结果的因素,如体重指数(BMI)、基础卵泡刺激素(FSH)和抗苗勒氏激素(AMH)进行了回顾性评估:结果:在招募的患者中,每个周期的临床妊娠率为 19.8%。在IVF-ET治疗后怀孕和未怀孕的患者在年龄、不孕时间和体重指数方面没有发现明显的统计学差异。临床妊娠患者的基础 FSH 水平明显较低(P=0.001),AMH 水平明显较高(P=0.001)。经计算,预测临床妊娠的基础 AMH 临界值为 3.34 ng/mL,基础 FSH 临界值为 7.26 IU/L:结论:IVF-ET治疗可作为不明原因不孕症的成功治疗方案。结论:IVF-ET治疗可作为不明原因不孕症的成功治疗方案,虽然基础FSH和AMH值不是具有高敏感性和特异性的临界值,但它们被认为与妊娠率有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prestimulation parameters predicting the pregnancy outcomes after IVF-ET in patients with unexplained infertility.

Objective: Assisted Reproductive Technologies (ART) are considered to be the most effective treatment option for unexplained infertility. This study aims to investigate the pregnancy outcomes of women who received in-vitro fertilization-embryo transfer (IVF-ET) treatment for unexplained infertility and the contributing factors affecting these outcomes.

Patients and methods: The present study included 789 consecutive women with unexplained infertility who were treated with IVF-ET at the ART Clinic of the Health Sciences University, Ankara Etlik Zübeyde Hanım Gynecology Training and Research Hospital between January 2007 and December 2019. The contributing factors affecting these outcomes, such as body mass index (BMI), basal follicle-stimulating hormone (FSH), and antimullerian hormone (AMH), were evaluated retrospectively.

Results: Clinical pregnancy per cycle was 19.8% among patients recruited. No statistically significant difference was detected in terms of age, infertility duration, and BMI of the patients who achieved pregnancy and who failed to get pregnant after IVF-ET treatment. The basal FSH level was found to be significantly lower (p=0.001), and the AMH level was significantly higher in patients who had clinical pregnancy (p=0.001). The basal AMH cut-off value was calculated to be 3.34 ng/mL, and the basal FSH cut-off value was calculated as 7.26 IU/L for the prediction of clinical pregnancy.

Conclusions: IVF-ET treatment can be applied as a successful treatment option in unexplained infertility cases. Although the basal FSH and AMH values ​are not the cut-off values that have high sensitivity and specificity, they are considered to be associated with pregnancy rates.

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来源期刊
CiteScore
5.30
自引率
6.10%
发文量
906
审稿时长
2-4 weeks
期刊介绍: European Review for Medical and Pharmacological Sciences, a fortnightly journal, acts as an information exchange tool on several aspects of medical and pharmacological sciences. It publishes reviews, original articles, and results from original research. The purposes of the Journal are to encourage interdisciplinary discussions and to contribute to the advancement of medicine. European Review for Medical and Pharmacological Sciences includes: -Editorials- Reviews- Original articles- Trials- Brief communications- Case reports (only if of particular interest and accompanied by a short review)
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