肿瘤代谢成像。

IF 7.8 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Cold Spring Harbor perspectives in medicine Pub Date : 2024-07-15 DOI:10.1101/cshperspect.a041551

Thomas Ruan, Kayvan R Keshari

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引用次数: 0

摘要

分子成像--绘制活体分子和细胞过程图--具有独特的能力，可在空间环境中检测癌症代谢。这项研究介绍了两种最先进的体内代谢成像模式：正电子发射断层扫描（PET）和磁共振（MR）。这些技术可用于探查糖酵解、谷氨酰胺代谢、合成代谢、氧化还原状态、缺氧和细胞外酸化。本综述旨在概述目前可用的分子成像策略的优势和局限性。

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Imaging Tumor Metabolism.

Molecular imaging-the mapping of molecular and cellular processes in vivo-has the unique capability to interrogate cancer metabolism in its spatial contexts. This work describes the usage of the two most developed modalities for imaging metabolism in vivo: positron emission tomography (PET) and magnetic resonance (MR). These techniques can be used to probe glycolysis, glutamine metabolism, anabolic metabolism, redox state, hypoxia, and extracellular acidification. This review aims to provide an overview of the strengths and limitations of currently available molecular imaging strategies.

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来源期刊

Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

14.30

自引率

1.90%

发文量

审稿时长

4-8 weeks

期刊介绍： Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.