碳纳米结构的前沿方法:中枢神经系统靶向给药。

Venishaa S, Mridul Guleria, Prashant Kumar, Mithun Bhowmick, Pratibha Bhowmick, Sumel Ashique, Iqbal Husain, Radheshyam Pal
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引用次数: 0

摘要

由于血脑屏障(BBB)具有高度半透性的特点,限制了各种药物进入中枢神经系统(CNS)治疗脑部疾病,因此通过血脑屏障(BBB)给药是现代医学面临的主要挑战之一。药物可以很容易地融入碳纳米载体中,从而穿越血脑屏障。目前已开发出许多纳米载体,包括聚合物纳米颗粒、碳纳米颗粒、脂基纳米颗粒等。其中,碳纳米结构因其更易穿透血脑屏障和较强的生物相容性而更具优势。一些碳点(CD)和碳点-配体共轭物已经探索出了有效穿透 BBB 的方法,这使得基于碳点的给药系统(DDS)在治疗中枢神经系统疾病方面取得了重大进展。尽管碳纳米结构可用于药物递送,但它们也可用作中枢神经系统(CNS)药物。此外,它们对神经元生长和抗淀粉样蛋白作用的影响也相当有趣。本研究涵盖了多种用于脑靶向给药的碳纳米结构,探讨了各种中枢神经系统活性。此外,本研究还强调了近期有关中枢神经系统疾病的碳纳米结构专利。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cutting-edge Approach of Carbon Nanostructures: Targeted Drug Delivery to Central Nervous System.

Drug delivery through the blood-brain barrier (BBB) is one of the key challenges in the modern era of medicine due to the highly semipermeable characteristics of BBB that restrict the entry of various drugs into the central nervous system (CNS) for the management of brain disorders. Drugs can be easily incorporated into carbon nanocarriers that can cross the bloodbrain barrier. Numerous nanocarriers have been developed, including polymeric nanoparticles, carbon nanoparticles, lipid-based nanoparticles, etc. Among these, carbon nanostructures could be superior due to their easier BBB penetration and strong biocompatibility. Several CDs (Carbon dots) and CD-ligand conjugates have explored effectively penetrating the BBB, which enables significant progress in using CD-based drug delivery systems (DDS) to manage CNS diseases. Despite the drug delivery applications, they might also be used as a central nervous system (CNS) drug; few of the carbon nanostructures show profound neurodegenerative activity. Further, their impact on neuronal growth and anti- amyloid action is quite interesting. The present study covers diverse carbon nanostructures for brain-targeted drug delivery, exploring a variety of CNS activities. Moreover, it emphasizes recent patents on carbon nanostructures for CNS disorders.

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