利用经皮心室辅助装置上的导入装置测量左心室容积。

IF 2.6 4区 医学 Q2 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
Luis A Diaz Sanmartin, Aleksandra B Gruslova, Drew R Nolen, Marc D Feldman, Jonathan W Valvano
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引用次数: 0

摘要

带有导入电极的经皮心室辅助装置(pVAD)已在动物实验中得到验证,可进行精确的瞬时容积测量。由于 pVAD 外形微型化是减少患者血管并发症的当务之急,我们的研究旨在验证使用三个电极而非标准的四个电极进行的导纳测量。通过有限元分析和在台式机上测量了一对电极和 pVAD 金属吸头之间的复合导纳。首先在左心室(LV)的椭圆形模型内模拟导管和电极阵列,结果表明电流流经左心室的所有部位,导管偏离中心位置对记录信号的影响极小。在健康心脏和扩张心脏(舒张末期容积为 100-400 mL)的三维打印模型中对导流测量进行了验证。结果表明,pVAD 电机与我们的导流系统电流信号之间的干扰极小。为了与临床上出现的带有导入电极和导线的缩小型 pVAD 相兼容,我们开发了一个修改后的魏氏方程,该方程以三个电极为中心。修改后的方程与魏氏原始方程进行了比较,结果显示计算容量的准确性有所提高。减少电极占位面积可简化在任何 pVAD 上采用导入技术的过程,从而可即时识别原生心脏的恢复情况并协助 pVAD 断流。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Measurement of left ventricular volume with admittance incorporated onto percutaneous ventricular assist device.

Measurement of left ventricular volume with admittance incorporated onto percutaneous ventricular assist device.

Percutaneous ventricular assist devices (pVADs) incorporated with admittance electrodes have been validated in animal studies for accurate instantaneous volumetric measurements. Since miniaturization of the pVAD profile is a priority to reduce vascular complications in patients, our study aimed to validate admittance measurements using three electrodes instead of the standard four. Complex admittance was measured between an electrode pair and a pVAD metallic blood-intake tip, both with finite element analysis and on the benchtop. The catheter and electrode arrays were first simulated inside prolate ellipsoid models of the left ventricle (LV) demonstrating current flow throughout all parts of the LV as well as minimal influence of off-center catheter placement in the recorded signal. Admittance measurements were validated in 3D-printed models of healthy and dilated hearts (100-400 mL end-diastolic volumes). Minimal interference between a pVAD motor and the current signal of our admittance system was demonstrated. A modified Wei's equation focused on three electrodes was developed to be compatible with reduced profile pVADs occurring clinically, incorporated with admittance electrodes and wires. The modified equation was compared against Wei's original equation showing improved accuracy of calculated volumes. Reducing electrode footprint can simplify the incorporation of Admittance technology on any pVAD, allowing for instantaneous recognition of native heart recovery and assistance with pVAD weaning.

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来源期刊
Medical & Biological Engineering & Computing
Medical & Biological Engineering & Computing 医学-工程:生物医学
CiteScore
6.00
自引率
3.10%
发文量
249
审稿时长
3.5 months
期刊介绍: Founded in 1963, Medical & Biological Engineering & Computing (MBEC) continues to serve the biomedical engineering community, covering the entire spectrum of biomedical and clinical engineering. The journal presents exciting and vital experimental and theoretical developments in biomedical science and technology, and reports on advances in computer-based methodologies in these multidisciplinary subjects. The journal also incorporates new and evolving technologies including cellular engineering and molecular imaging. MBEC publishes original research articles as well as reviews and technical notes. Its Rapid Communications category focuses on material of immediate value to the readership, while the Controversies section provides a forum to exchange views on selected issues, stimulating a vigorous and informed debate in this exciting and high profile field. MBEC is an official journal of the International Federation of Medical and Biological Engineering (IFMBE).
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