与昆虫痘病毒相关的超寄生病毒的基因组分析

IF 5.5 2区医学 Q1 VIROLOGY

Virus Evolution Pub Date : 2024-07-12 DOI:10.1093/ve/veae051

Zachary K Barth, Ian Hicklin, Julien Thézé, Jun Takatsuka, Madoka Nakai, Elisabeth A Herniou, Anne M Brown, Frank O Aylward

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引用次数: 0

摘要

类波林顿病毒（Polinton-like viruses，PLVs）是一类感染多种真核生物宿主的小型整合dsDNA病毒。据推测，许多PLV寄生在核细胞病毒门中的病毒上，以实现自身的繁殖和传播。在这里，我们分析了新型 PLV 的基因组，这些 PLV 与两种不同的鳞翅目寄主感染的昆虫疱疹病毒（EV）闭塞体有关。EV闭塞体中存在的这些元素表明，它们是已知的第一种痘病毒超寄生虫。我们发现，这些 PLV 属于两个不同的品系，与已知的 PLV 高度不同。这些 PLV 具有镶嵌基因组，其中一些重要基因与 EVs 中的移动基因具有同源性。基于这种同源性和观察到的PLV镶嵌现象，我们提出了一种机制来解释PLV复制和整合基因的更替。

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Genomic analysis of hyperparasitic viruses associated with entomopoxviruses

Polinton-like viruses (PLVs) are a diverse group of small integrative dsDNA viruses that infect diverse eukaryotic hosts. Many PLVs are hypothesized to parasitize viruses in the phylum Nucleocytoviricota for their own propagation and spread. Here we analyze the genomes of novel PLVs associated with the occlusion bodies of entomopoxvirus (EV) infections of two separate lepidopteran hosts. The presence of these elements within EV occlusion bodies suggests that they are the first known hyperparasites of poxviruses. We find that these PLVs belong to two distinct lineages that are highly diverged from known PLVs. These PLVs possess mosaic genomes, and some essential genes share homology with mobile genes within EVs. Based on this homology and observed PLV mosaicism, we propose a mechanism to explain the turnover of PLV replication and integration genes.

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来源期刊

Virus Evolution Immunology and Microbiology-Microbiology

CiteScore

10.50

自引率

5.70%

发文量

108

审稿时长

14 weeks

期刊介绍： Virus Evolution is a new Open Access journal focusing on the long-term evolution of viruses, viruses as a model system for studying evolutionary processes, viral molecular epidemiology and environmental virology. The aim of the journal is to provide a forum for original research papers, reviews, commentaries and a venue for in-depth discussion on the topics relevant to virus evolution.