兽用 mRNA 疫苗平台

IF 1.4 3区 农林科学 Q4 IMMUNOLOGY
Fatemeh Fazel, Janan Shoja Doost, Sugandha Raj, Nitish Boodhoo, Khalil Karimi, Shayan Sharif
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引用次数: 0

摘要

事实证明,接种疫苗是控制动物体内病原体的有效手段。自 19 世纪引入兽用疫苗以来,已经推出了几代疫苗。这些疫苗对全球动物健康和生产产生了积极影响。尽管兽用疫苗取得了成功,但仍有一些病原体没有有效的疫苗可用,如非洲猪瘟。此外,动物健康还不断受到新出现和再次出现的病原体的威胁,其中一些是人畜共患病,可对人类健康构成威胁。严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)大流行凸显了对安全、有效的新型疫苗平台的需求,但更重要的是,这种疫苗平台必须具有适应性,能够根据流行病原体的不同而迅速改变。本综述将介绍兽用 mRNA 疫苗领域的一些最新进展。此外,还将讨论各种 mRNA 疫苗及其输送方法,以及它们的疗效报告。还将讨论这种疫苗平台在兽医领域的当前局限性和未来前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The mRNA vaccine platform for veterinary species

Vaccination has proven to be an effective means of controlling pathogens in animals. Since the introduction of veterinary vaccines in the 19th century, several generations of vaccines have been introduced. These vaccines have had a positive impact on global animal health and production. Despite, the success of veterinary vaccines, there are still some pathogens for which there are no effective vaccines available, such as African swine fever. Further, animal health is under the constant threat of emerging and re-emerging pathogens, some of which are zoonotic and can pose a threat to human health. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has highlighted the need for new vaccine platforms that are safe and efficacious, but also importantly, are adaptable and can be modified rapidly to match the circulating pathogens. mRNA vaccines have been shown to be an effective vaccine platform against various viral and bacterial pathogens. This review will cover some of the recent advances in the field of mRNA vaccines for veterinary species. Moreover, various mRNA vaccines and their delivery methods, as well as their reported efficacy, will be discussed. Current limitations and future prospects of this vaccine platform in veterinary medicine will also be discussed.

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来源期刊
CiteScore
3.40
自引率
5.60%
发文量
79
审稿时长
70 days
期刊介绍: The journal reports basic, comparative and clinical immunology as they pertain to the animal species designated here: livestock, poultry, and fish species that are major food animals and companion animals such as cats, dogs, horses and camels, and wildlife species that act as reservoirs for food, companion or human infectious diseases, or as models for human disease. Rodent models of infectious diseases that are of importance in the animal species indicated above,when the disease requires a level of containment that is not readily available for larger animal experimentation (ABSL3), will be considered. Papers on rabbits, lizards, guinea pigs, badgers, armadillos, elephants, antelope, and buffalo will be reviewed if the research advances our fundamental understanding of immunology, or if they act as a reservoir of infectious disease for the primary animal species designated above, or for humans. Manuscripts employing other species will be reviewed if justified as fitting into the categories above. The following topics are appropriate: biology of cells and mechanisms of the immune system, immunochemistry, immunodeficiencies, immunodiagnosis, immunogenetics, immunopathology, immunology of infectious disease and tumors, immunoprophylaxis including vaccine development and delivery, immunological aspects of pregnancy including passive immunity, autoimmuity, neuroimmunology, and transplanatation immunology. Manuscripts that describe new genes and development of tools such as monoclonal antibodies are also of interest when part of a larger biological study. Studies employing extracts or constituents (plant extracts, feed additives or microbiome) must be sufficiently defined to be reproduced in other laboratories and also provide evidence for possible mechanisms and not simply show an effect on the immune system.
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