作为线粒体载体的细胞外囊泡：生物功能和临床应用。

IF 3.9 3区生物学 Q2 CELL BIOLOGY

Mitochondrion Pub Date : 2024-07-11 DOI:10.1016/j.mito.2024.101935

Zhiwei Liao , Bide Tong , Wencan Ke , Cao Yang, Xinghuo Wu, Ming Lei

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引用次数: 0

摘要

近年来，越来越多的研究集中于细胞外囊泡（EVs）的生物生成及其内容物的分拣机制。线粒体可以有选择性地装载到EVs中，作为维持细胞线粒体平衡的一种方式。研究还表明，EV介导的线粒体转移对目标细胞的功能有很大影响。基于 EV 介导的线粒体转移机制，可以开发出治疗人类疾病的疗法。本综述总结了 EVs 的生物发生和分子组成方面的最新进展。它还强调了线粒体成分进入 EVs 的分拣和转运机制。此外，它还探讨了目前由 EV 介导的线粒体转运在人类疾病发展中的作用及其诊断和治疗应用。

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Extracellular vesicles as carriers for mitochondria: Biological functions and clinical applications

In recent years, research has increasingly focused on the biogenesis of extracellular vesicles (EVs) and the sorting mechanisms for their contents. Mitochondria can be selectively loaded into EVs, serving as a way to maintain cellular mitochondrial homeostasis. EV-mediated mitochondrial transfer has also been shown to greatly impact the function of target cells. Based on the mechanism of EV-mediated mitochondrial transfer, therapies can be developed to treat human diseases. This review summarizes the recent advances in the biogenesis and molecular composition of EVs. It also highlights the sorting and trafficking mechanisms of mitochondrial components into EVs. Furthermore, it explores the current role of EV-mediated mitochondrial transfer in the development of human diseases, as well as its diagnostic and therapeutic applications.

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.