SCOT-HEART 2 试验的原理和设计:预防心肌梗死的 CT 血管造影。

IF 12.8 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Michael McDermott MBChB , Mohammed N. Meah MBChB, PhD , Phyo Khaing MBChB , Kang-Ling Wang MD , Jennifer Ramsay MBChB , Gillian Scott PhD , Hannah Rickman MPH , Tom Burt , Ian McGowan , Timothy Fairbairn MBChB, PhD , Marise Bucukoglu , Russell Bull MBBChir , Adam Timmis MBChB, PhD , Edwin J.R. van Beek MD, PhD , Giles Roditi MBChB , Philip D. Adamson MBChB, PhD, MPH , Steff Lewis MSC, PhD , John Norrie MSc , Brian McKinstry MBChB, MD , Bruce Guthrie MBChB, PhD , David E. Newby MBChB, PhD
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引用次数: 0

摘要

冠状动脉疾病仍然是全球死亡的主要原因。识别冠心病高危患者仍然是公共卫生的当务之急。目前,心血管疾病预防的重点主要依赖于概率风险评分,尽管没有随机对照试验证明其有效性。使用成像技术指导预防性治疗并不是新概念,但以前一直侧重于间接测量,如颈动脉内膜中层增厚或冠状动脉钙化。在最近的试验中,通过计算机断层扫描(CT)冠状动脉造影发现患有冠状动脉疾病的患者更有可能开始接受预防性治疗,而且心脏事件发生率较低。因此,我们设计了 SCOT-HEART 2(苏格兰心脏计算机断层扫描 2)试验,旨在确定使用 CT 冠状动脉造影术进行筛查是否比心血管风险评分在临床上更有效,从而指导使用一级预防疗法并降低心肌梗死的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rationale and Design of SCOT-HEART 2 Trial

Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relies heavily on probabilistic risk scoring despite no randomized controlled trials demonstrating their efficacy. The concept of using imaging to guide preventative therapy is not new, but has previously focused on indirect measures such as carotid intima-media thickening or coronary artery calcification. In recent trials, patients found to have coronary artery disease on computed tomography (CT) coronary angiography were more likely to be started on preventative therapy and had lower rates of cardiac events. This led to the design of the SCOT-HEART 2 (Scottish Computed Tomography of the Heart 2) trial, which aims to determine whether screening with the use of CT coronary angiography is more clinically effective than cardiovascular risk scoring to guide the use of primary preventative therapies and reduce the risk of myocardial infarction.

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来源期刊
JACC. Cardiovascular imaging
JACC. Cardiovascular imaging CARDIAC & CARDIOVASCULAR SYSTEMS-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
24.90
自引率
5.70%
发文量
330
审稿时长
4-8 weeks
期刊介绍: JACC: Cardiovascular Imaging, part of the prestigious Journal of the American College of Cardiology (JACC) family, offers readers a comprehensive perspective on all aspects of cardiovascular imaging. This specialist journal covers original clinical research on both non-invasive and invasive imaging techniques, including echocardiography, CT, CMR, nuclear, optical imaging, and cine-angiography. JACC. Cardiovascular imaging highlights advances in basic science and molecular imaging that are expected to significantly impact clinical practice in the next decade. This influence encompasses improvements in diagnostic performance, enhanced understanding of the pathogenetic basis of diseases, and advancements in therapy. In addition to cutting-edge research,the content of JACC: Cardiovascular Imaging emphasizes practical aspects for the practicing cardiologist, including advocacy and practice management.The journal also features state-of-the-art reviews, ensuring a well-rounded and insightful resource for professionals in the field of cardiovascular imaging.
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