Harmine 通过抑制 FAK/AKT 和 ERK1/2/CREB 信号通路，抑制结肠癌细胞的增殖和迁移，并促进其凋亡。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-07-13 DOI:10.1080/10286020.2024.2361767

Fu-Hong Liu, Xing-Cheng Lin, Yu-Wei Liu, Tian-Tian Zhang, Yang-Bo Zhang, Zhuo-Long Xie, Yuan Zhan, Ping Hu

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引用次数: 0

摘要

胭脂虫碱存在于多种药用植物中，它对结肠癌细胞的影响尚不清楚。在这里，我们发现鹤顶红通过抑制FAK/AKT和ERK1/2/CREB的磷酸化水平，对结肠癌细胞的增殖有明显的抑制作用。此外，鹤顶红还能抑制结肠癌细胞的迁移，并抑制MMP-2、MMP-9和血管内皮生长因子的表达水平。此外，加害碱还能通过调节 Bcl-2 和 Bax 的表达诱导结肠癌细胞凋亡。总之，我们的研究结果表明，鹤顶红对结肠癌细胞的发展具有显著的抑制作用。

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Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK_1/2/CREB signaling pathways.

Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the phosphorylation levels of the FAK/AKT and ERK1/2/CREB. Furthermore, harmine also inhibited the migration of colon cancer cells and suppressed the expression levels of MMP-2, MMP-9, and VEGF. Additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of Bcl-2 and Bax. In conclusion, our findings suggest that harmine exerts a significant inhibitory effect on the development of colon cancer cells.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.