老龄化过程中性别特异性因素对生物转化和健康结果的影响。

IF 4.4 4区医学 Q1 GERIATRICS & GERONTOLOGY

Biogerontology Pub Date : 2024-10-01 Epub Date: 2024-07-13 DOI:10.1007/s10522-024-10121-x

Yongyin Huang, Hongyu Li, Runyu Liang, Jia Chen, Qiang Tang

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引用次数: 0

摘要

男性和女性在衰老过程中存在明显差异，这是影响疾病易感性和寿命的关键因素。性染色体的差异是生物体内存在性别偏见的根本原因。此外，性别特异性表观遗传修饰和性激素水平的变化对胚胎发育期及以后的免疫力发展产生了不同的影响。线粒体、端粒、家动力空间和肠道菌群与衰老的性别差异有着错综复杂的联系。这些因素会对男性和女性产生不同的影响，从而导致他们在变老过程中产生独特的生物转化和健康结果。这篇综述探讨了性别如何与这些元素相互作用并塑造衰老过程。

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The influence of sex-specific factors on biological transformations and health outcomes in aging processes.

The aging process demonstrates notable differences between males and females, which are key factors in disease susceptibility and lifespan. The differences in sex chromosomes are fundamental to the presence of sex bias in organisms. Moreover, sex-specific epigenetic modifications and changes in sex hormone levels impact the development of immunity differently during embryonic development and beyond. Mitochondria, telomeres, homeodynamic space, and intestinal flora are intricately connected to sex differences in aging. These elements can have diverse effects on men and women, resulting in unique biological transformations and health outcomes as they grow older. This review explores how sex interacts with these elements and shapes the aging process.

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来源期刊

Biogerontology 医学-老年医学

CiteScore

8.00

自引率

4.40%

发文量

审稿时长

>12 weeks

期刊介绍： The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.