患有癌症和常见并发症的老年人--改善癌症治疗效果的挑战与机遇。

IF 9.9 1区 医学 Q1 ONCOLOGY
Weiwei Chen, Rachel D Altshuler, Phil Daschner, Carolina Salvador Morales, Diane C St Germain, Jennifer Guida, Pataje G S Prasanna, Jeffrey C Buchsbaum
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引用次数: 0

摘要

美国老年人口正在迅速增加,数百万老年人将成为癌症幸存者并伴有合并症。这一人群面临着治疗方面的特殊挑战,有着独特的临床需求。认识到这一需求,美国国家癌症研究所(NCI)与美国国家老龄化研究所(NIA)合作举办了题为 "癌症、老龄化和合并症 "的系列网络研讨会。本评论反映了该系列网络研讨会涉及的五个主题领域,其重点是改善患有癌症和合并症的老年人的癌症治疗:i) 合并症对治疗耐受性和患者预后的影响;ii) 合并症对癌症临床试验设计的影响;iii) 开发可穿戴设备以测量癌症治疗中的合并症;iv) 营养和微生物组对癌症治疗的影响;v) 衰老和老年疗法在老年相关疾病中的作用。虽然在这些领域取得了进展,但仍存在许多差距和挑战,本评论将对此进行讨论。为了提高有合并症的老年人群的癌症生存率,必须共同考虑衰老和合并症,并将其纳入癌症研究的各个领域。这包括对合并症与癌症发展和治疗反应之间的关联机制进行更多基础研究,建立关键资源和基础设施(如临床前模型和患者样本),开展以老年人群为重点的临床试验,将老年病学评估纳入癌症治疗,以及将可穿戴设备等新技术纳入临床试验和癌症护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Older adults with cancer and common comorbidities-challenges and opportunities in improving their cancer treatment outcomes.

The older American population is rapidly increasing, and millions of older adults will be cancer survivors with comorbidities. This population faces specific challenges regarding treatment and has unique clinical needs. Recognizing this need, the National Cancer Institute, in collaboration with the National Institute on Aging, hosted a webinar series, entitled Cancer, Aging, and Comorbidities. This commentary provides a reflection of 5 thematic areas covered by the webinar series, which was focused on improving cancer treatment for older adults with cancer and comorbidities: 1) the impact of comorbidities on treatment tolerability and patient outcomes; 2) the impact of comorbidities on cancer clinical trial design; 3) the development of wearable devices in measuring comorbidities in cancer treatment; 4) the effects of nutrition and the microbiome on cancer therapy; and 5) the role of senescence and senotherapy in age-related diseases. Advances have been made in these areas, however, many gaps and challenges exist and are discussed in this commentary. To improve cancer survivorship in older populations with comorbidities, aging and comorbidities must be jointly considered and incorporated across the spectrum of cancer research. This includes more basic research of the mechanisms linking comorbidities and cancer development and treatment response, building critical resources and infrastructure (eg, preclinical models and patient samples), conducting clinical trials focused on the older population, integrating geriatric assessment into cancer treatment, and incorporating novel technologies, such as wearable devices, into clinical trials and cancer care.

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来源期刊
CiteScore
17.00
自引率
2.90%
发文量
203
审稿时长
4-8 weeks
期刊介绍: The Journal of the National Cancer Institute is a reputable publication that undergoes a peer-review process. It is available in both print (ISSN: 0027-8874) and online (ISSN: 1460-2105) formats, with 12 issues released annually. The journal's primary aim is to disseminate innovative and important discoveries in the field of cancer research, with specific emphasis on clinical, epidemiologic, behavioral, and health outcomes studies. Authors are encouraged to submit reviews, minireviews, and commentaries. The journal ensures that submitted manuscripts undergo a rigorous and expedited review to publish scientifically and medically significant findings in a timely manner.
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