某些群体中 sFlt-1/PlGF 比率的意义--需要考虑哪些因素?

IF 2.4 4区 医学 Q2 OBSTETRICS & GYNECOLOGY
Geburtshilfe Und Frauenheilkunde Pub Date : 2024-07-09 eCollection Date: 2024-07-01 DOI:10.1055/a-2320-5843
Oliver Graupner, Stefan Verlohren, Tanja Groten, Dietmar Schlembach, Holger Stepan, Bettina Kuschel, Anne Karge, Ulrich Pecks
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引用次数: 0

摘要

在临床实践中,sFlt-1/PlGF 比值是一种成熟的工具,它是诊断算法的一部分,并为子痫前期(PE)的预后提供依据。母体和妊娠合并症会影响 sFlt-1/PlGF 比值及其组成要素的性能,因此需要充分了解潜在的误区。本文旨在对有关特定患者群中 sFlt-1/PlGF 比值的诊断和预测性能的文献进行叙述性综述。可能对 sFlt-1/PlGF 比值的临床可解释性和适用性产生负面影响的潜在因素包括慢性肾病、双胎妊娠和产妇肥胖。与这些因素和疾病相关的病理生理机制会导致母体血液中 sFlt-1 和/或 PlGF 的浓度不同,这意味着在特定人群中使用标准临界值可能会导致误差。只有在大型前瞻性队列研究中才能明确在特定患者队列中应在多大程度上调整临界值。这也适用于将比值用于诊断和预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Significance of the sFlt-1/PlGF Ratio in Certain Cohorts - What Needs to be Considered?

The sFlt-1/PlGF ratio is an established tool in clinical practice, where it is part of a diagnostic algorithm and informs the prognosis of preeclampsia (PE). Maternal and gestational comorbidities can affect the performance of the sFlt-1/PlGF ratio and its constituent elements, and a good understanding of the potential pitfalls is required. The objective of this paper was to provide a current narrative review of the literature on the diagnostic and predictive performance of the sFlt-1/PlGF ratio in specific patient cohorts. Potential factors which can negatively affect the clinical interpretability and applicability of the sFlt-1/PlGF ratio include chronic kidney disease, twin pregnancy, and maternal obesity. Pathophysiological mechanisms related to these factors and disorders can result in different concentrations of sFlt-1 and/or PlGF in maternal blood, meaning that the use of standard cut-off values in specific cohorts can lead to errors. To what extent the cut-off values should be adapted in certain patient cohorts can only be clarified in large prospective cohort studies. This applies to the use of the ratio both for diagnosis and prognosis.

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来源期刊
Geburtshilfe Und Frauenheilkunde
Geburtshilfe Und Frauenheilkunde 医学-妇产科学
CiteScore
2.50
自引率
22.20%
发文量
828
审稿时长
6-12 weeks
期刊介绍: Geburtshilfe und Frauenheilkunde (GebFra) addresses the whole field of obstetrics and gynecology and is concerned with research as much as with clinical practice. In its scientific section, it publishes original articles, reviews and case reports in all fields of the discipline, namely gynecological oncology, including oncology of the breast obstetrics and perinatal medicine, reproductive medicine, and urogynecology. GebFra invites the submission of original articles and review articles. In addition, the journal publishes guidelines, statements and recommendations in cooperation with the DGGG, SGGG, OEGGG and the Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF, Association of Scientific Medical Societies, www.awmf.org). Apart from the scientific section, Geburtshilfe und Frauenheilkunde has a news and views section that also includes discussions, book reviews and professional information. Letters to the editors are welcome. If a letter discusses an article that has been published in our journal, the corresponding author of the article will be informed and invited to comment on the letter. The comment will be published along with the letter.
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